Visualizing spikes in source-space: Rapid and efficient evaluation of magnetoencephalography

Sándor Beniczky; Lene Duez; Michael Scherg; Peter Orm Hansen; Hatice Tankisi; Per Sidenius; Anne Sabers; Lars Hageman Pinborg; Peter Uldall; Anders Fuglsang-Frederiksen

doi:10.1016/j.clinph.2015.07.017

Visualizing spikes in source-space: Rapid and efficient evaluation of magnetoencephalography

Sándor Beniczky, Lene Duez, Michael Scherg, Peter Orm Hansen, Hatice Tankisi, Per Sidenius, Anne Sabers, Lars Hageman Pinborg, Peter Uldall, Anders Fuglsang-Frederiksen

9 Citations (Scopus)

Abstract

OBJECTIVE: Reviewing magnetoencephalography (MEG) recordings is time-consuming: signals from the 306 MEG-sensors are typically reviewed divided into six arrays of 51 sensors each, thus browsing each recording six times in order to evaluate all signals. A novel method of reconstructing the MEG signals in source-space was developed using a source-montage of 29 brain-regions and two spatial components to remove magnetocardiographic (MKG) artefacts. Our objective was to evaluate the accuracy of reviewing MEG in source-space.

METHODS: In 60 consecutive patients with epilepsy, we prospectively evaluated the accuracy of reviewing the MEG signals in source-space as compared to the classical method of reviewing them in sensor-space.

RESULTS: All 46 spike-clusters identified in sensor-space were also identified in source-space. Two additional spike-clusters were identified in source-space. As 29 source-channels can be easily displayed simultaneously, MEG recordings had to be browsed only once. Yet, this yielded a global coverage of the recorded signals and enhanced detectability of epileptiform discharges because MKG-artefacts were suppressed and did not impede evaluation in source-space.

CONCLUSIONS: Our results show that reviewing MEG recordings in source-space is accurate and much more rapid than the classical method of reviewing in sensor-space.

SIGNIFICANCE: This novel method facilitates the clinical use of MEG.

Original language	English
Journal	Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Volume	127
Issue number	2
Pages (from-to)	1067–1072
ISSN	1388-2457
DOIs	https://doi.org/10.1016/j.clinph.2015.07.017
Publication status	Published - 2016

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10.1016/j.clinph.2015.07.017

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Beniczky, S., Duez, L., Scherg, M., Hansen, P. O., Tankisi, H., Sidenius, P., Sabers, A., Pinborg, L. H., Uldall, P., & Fuglsang-Frederiksen, A. (2016). Visualizing spikes in source-space: Rapid and efficient evaluation of magnetoencephalography. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 127 (2), 1067–1072. https://doi.org/10.1016/j.clinph.2015.07.017

Visualizing spikes in source-space: Rapid and efficient evaluation of magnetoencephalography. / Beniczky, Sándor; Duez, Lene; Scherg, Michael et al.
In: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, Vol. 127 , No. 2, 2016, p. 1067–1072.

Research output: Contribution to journal › Journal article › Research › peer-review

Beniczky, S, Duez, L, Scherg, M, Hansen, PO, Tankisi, H, Sidenius, P, Sabers, A , Pinborg, LH , Uldall, P & Fuglsang-Frederiksen, A 2016, 'Visualizing spikes in source-space: Rapid and efficient evaluation of magnetoencephalography', Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, vol. 127 , no. 2, pp. 1067–1072. https://doi.org/10.1016/j.clinph.2015.07.017

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abstract = "OBJECTIVE: Reviewing magnetoencephalography (MEG) recordings is time-consuming: signals from the 306 MEG-sensors are typically reviewed divided into six arrays of 51 sensors each, thus browsing each recording six times in order to evaluate all signals. A novel method of reconstructing the MEG signals in source-space was developed using a source-montage of 29 brain-regions and two spatial components to remove magnetocardiographic (MKG) artefacts. Our objective was to evaluate the accuracy of reviewing MEG in source-space.METHODS: In 60 consecutive patients with epilepsy, we prospectively evaluated the accuracy of reviewing the MEG signals in source-space as compared to the classical method of reviewing them in sensor-space.RESULTS: All 46 spike-clusters identified in sensor-space were also identified in source-space. Two additional spike-clusters were identified in source-space. As 29 source-channels can be easily displayed simultaneously, MEG recordings had to be browsed only once. Yet, this yielded a global coverage of the recorded signals and enhanced detectability of epileptiform discharges because MKG-artefacts were suppressed and did not impede evaluation in source-space.CONCLUSIONS: Our results show that reviewing MEG recordings in source-space is accurate and much more rapid than the classical method of reviewing in sensor-space.SIGNIFICANCE: This novel method facilitates the clinical use of MEG.",

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T2 - Rapid and efficient evaluation of magnetoencephalography

AU - Beniczky, Sándor

AU - Duez, Lene

AU - Scherg, Michael

AU - Hansen, Peter Orm

AU - Tankisi, Hatice

AU - Sidenius, Per

AU - Sabers, Anne

AU - Pinborg, Lars Hageman

AU - Uldall, Peter

AU - Fuglsang-Frederiksen, Anders

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AB - OBJECTIVE: Reviewing magnetoencephalography (MEG) recordings is time-consuming: signals from the 306 MEG-sensors are typically reviewed divided into six arrays of 51 sensors each, thus browsing each recording six times in order to evaluate all signals. A novel method of reconstructing the MEG signals in source-space was developed using a source-montage of 29 brain-regions and two spatial components to remove magnetocardiographic (MKG) artefacts. Our objective was to evaluate the accuracy of reviewing MEG in source-space.METHODS: In 60 consecutive patients with epilepsy, we prospectively evaluated the accuracy of reviewing the MEG signals in source-space as compared to the classical method of reviewing them in sensor-space.RESULTS: All 46 spike-clusters identified in sensor-space were also identified in source-space. Two additional spike-clusters were identified in source-space. As 29 source-channels can be easily displayed simultaneously, MEG recordings had to be browsed only once. Yet, this yielded a global coverage of the recorded signals and enhanced detectability of epileptiform discharges because MKG-artefacts were suppressed and did not impede evaluation in source-space.CONCLUSIONS: Our results show that reviewing MEG recordings in source-space is accurate and much more rapid than the classical method of reviewing in sensor-space.SIGNIFICANCE: This novel method facilitates the clinical use of MEG.

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Visualizing spikes in source-space: Rapid and efficient evaluation of magnetoencephalography

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