Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Visual steady state in relation to age and cognitive function

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Reward signalling in brainstem nuclei under fluctuating blood glucose

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Experiences managing pregnant hospital staff members using an active management policy-A qualitative study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Histological outcomes in HPV-screened elderly women in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Brain capillary pericytes and neurovascular coupling

    Research output: Contribution to journalReviewpeer-review

  2. ATP induces contraction of cultured brain capillary pericytes via activation of P2Y-type purinergic receptors

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Male fertility before and after androgen abuse

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Tidligt skift fra intravenøs fra intravenøs til antibiotikabehandling

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Neocortical gamma activity is crucial for sensory perception and cognition. This study examines the value of using non-task stimulation-induced EEG oscillations to predict cognitive status in a birth cohort of healthy Danish males (Metropolit) with varying cognitive ability. In particular, we examine the steady-state VEP power response (SSVEP-PR) in the alpha (8Hz) and gamma (36Hz) bands in 54 males (avg. age: 62.0 years) and compare these with 10 young healthy participants (avg. age 27.6 years). Furthermore, we correlate the individual alpha-to-gamma difference in relative visual-area power (ΔRV) with cognitive scores for the older adults. We find that ΔRV decrease with age by just over one standard deviation when comparing young with old participants (p<0.01). Furthermore, intelligence is significantly negatively correlated with ΔRV in the older adult cohort, even when processing speed, global cognition, executive function, memory, and education (p<0.05). In our preferred specification, an increase in ΔRV of one standard deviation is associated with a reduction in intelligence of 48% of a standard deviation (p<0.01). Finally, we conclude that the difference in cerebral rhythmic activity between the alpha and gamma bands is associated with age and cognitive status, and that ΔRV therefore provide a non-subjective clinical tool with which to examine cognitive status in old age.

Original languageEnglish
JournalP L o S One
Volume12
Issue number2
Pages (from-to)e0171859
ISSN1932-6203
DOIs
Publication statusPublished - 2017

    Research areas

  • Adult, Age Factors, Aged, Artifacts, Cognition, Cognition Disorders, Cohort Studies, Computer Simulation, Denmark, Electroencephalography, Female, Fourier Analysis, Humans, Intelligence, Male, Memory, Middle Aged, Neuropsychological Tests, ROC Curve, Reproducibility of Results, Social Class, Vision, Ocular, Journal Article

ID: 52613788