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Virus-specific antibody indices may supplement the total IgG index in diagnostics of multiple sclerosis

Research output: Contribution to journalJournal articlepeer-review

  1. Immunological effects of dimethyl fumarate treatment in blood and CSF of patients with primary progressive MS

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  2. Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis

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  3. MAIT cell subtypes in multiple sclerosis

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  4. Expression of melanoma cell adhesion molecule-1 (MCAM-1) in natalizumab-treated multiple sclerosis

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  5. Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

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Intrathecal antibody synthesis to viruses is associated with multiple sclerosis (MS). Here, IgG levels to Epstein-Barr virus (EBV) BamHI-A rightward frame 1 (BARF1), EBV nuclear antigen 1 (EBNA1), mumps virus (MuV) nucleoprotein (NuP), measles virus (MeV) NuP and rubella virus (RuV) capsid protein (CaP) were found to be elevated in serum and cerebrospinal fluid (CSF) of MS patients compared to healthy controls (HCs), whereas the opposite was found for cytomegalovirus (CMV) pp52. Strong correlations between serum and CSF IgG were seen for MeV, CMV and RuV in both MS patients and HCs. The antigen panel obtained high sensitivity (81%) and specificity (86%), demonstrating that antigen panels may supplement the total IgG index used in MS diagnosis.

Original languageEnglish
Article number577868
JournalJournal of Neuroimmunology
Volume367
Number of pages9
ISSN0165-5728
DOIs
Publication statusPublished - 15 Jun 2022

Bibliographical note

Copyright © 2022 Elsevier B.V. All rights reserved.

    Research areas

  • Antibody index, Antigen, Cerebrospinal fluid, Multiple sclerosis, Oligoclonal bands, Serum, Virus

ID: 77893456