Abstract
As cases of gallbladder-related adverse events have been reported in patients treated with glucagon-like peptide (GLP)-1 receptor agonists and GLP-2 receptor agonists, studies have investigated the effects of these hormones on the enterohepatic circulation of bile acids and gallbladder motility. Results suggest, that bile acids and GLP-2 counteract postprandial cholecystokinin-mediated gallbladder contraction, while GLP-1 may delay gallbladder refilling. This provides important information on the effect and safety of drugs based on GLP-1 and GLP-2, respectively.
| Translated title of the contribution | Effects of glucagon-like peptides on gallbladder motility |
|---|---|
| Original language | Danish |
| Journal | Ugeskrift for Laeger |
| Volume | 180 |
| Issue number | 50 |
| ISSN | 0041-5782 |
| Publication status | Published - 10 Dec 2018 |