Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction

Nynne Dose; Marie Mide Michelsen; Naja Dam Mygind; Adam Pena; Christina Ellervik; Peter R Hansen; Jørgen K Kanters; Eva Prescott; Jens Kastrup; Ida Gustafsson; Henrik Steen Hansen; Steering Committee of the iPOWER study

doi:10.1016/j.jelectrocard.2017.08.017

Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction

Nynne Dose, Marie Mide Michelsen, Naja Dam Mygind, Adam Pena, Christina Ellervik, Peter R Hansen, Jørgen K Kanters, Eva Prescott, Jens Kastrup, Ida Gustafsson, Henrik Steen Hansen, Steering Committee of the iPOWER study

7 Citations (Scopus)

Abstract

OBJECTIVES: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD.

METHODS: Women with angina pectoris and no obstructive coronary artery disease (n=138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch. CMD was assessed as a coronary flow velocity reserve (CFVR) by transthoracic echocardiography.

RESULTS: Women with angina pectoris had significantly longer QTc intervals (429±20ms) and increased MCS (IQR) (0.73 [0.64-0.80]) compared with the controls (419±20ms) and (0.63 [(0.53-0.73]), respectively (both p<0.001). CFVR was associated with longer QTc interval (p=0.02), but the association was attenuated after multivariable adjustment (p=0.08).

CONCLUSION: This study suggests that women with angina pectoris have alterations in T-wave morphology as well as longer QTc interval compared with a reference population. CMD might be an explanation.

Original language	English
Journal	Journal of Electrocardiology
Volume	51
Issue number	1
Pages (from-to)	15-20
ISSN	0022-0736
DOIs	https://doi.org/10.1016/j.jelectrocard.2017.08.017
Publication status	Published - Feb 2018

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Journal Article

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10.1016/j.jelectrocard.2017.08.017

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Dose, N., Michelsen, M. M., Mygind, N. D., Pena, A., Ellervik, C., Hansen, P. R., Kanters, J. K., Prescott, E., Kastrup, J., Gustafsson, I., Hansen, H. S., & Steering Committee of the iPOWER study (2018). Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction. Journal of Electrocardiology, 51(1), 15-20. https://doi.org/10.1016/j.jelectrocard.2017.08.017

Dose, N, Michelsen, MM, Mygind, ND, Pena, A, Ellervik, C, Hansen, PR, Kanters, JK, Prescott, E , Kastrup, J , Gustafsson, I, Hansen, HS & Steering Committee of the iPOWER study 2018, 'Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction', Journal of Electrocardiology, vol. 51, no. 1, pp. 15-20. https://doi.org/10.1016/j.jelectrocard.2017.08.017

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abstract = "OBJECTIVES: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD.METHODS: Women with angina pectoris and no obstructive coronary artery disease (n=138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch. CMD was assessed as a coronary flow velocity reserve (CFVR) by transthoracic echocardiography.RESULTS: Women with angina pectoris had significantly longer QTc intervals (429±20ms) and increased MCS (IQR) (0.73 [0.64-0.80]) compared with the controls (419±20ms) and (0.63 [(0.53-0.73]), respectively (both p<0.001). CFVR was associated with longer QTc interval (p=0.02), but the association was attenuated after multivariable adjustment (p=0.08).CONCLUSION: This study suggests that women with angina pectoris have alterations in T-wave morphology as well as longer QTc interval compared with a reference population. CMD might be an explanation.",

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T1 - Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction

AU - Dose, Nynne

AU - Michelsen, Marie Mide

AU - Mygind, Naja Dam

AU - Pena, Adam

AU - Ellervik, Christina

AU - Hansen, Peter R

AU - Kanters, Jørgen K

AU - Prescott, Eva

AU - Kastrup, Jens

AU - Gustafsson, Ida

AU - Hansen, Henrik Steen

AU - Steering Committee of the iPOWER study

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N2 - OBJECTIVES: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD.METHODS: Women with angina pectoris and no obstructive coronary artery disease (n=138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch. CMD was assessed as a coronary flow velocity reserve (CFVR) by transthoracic echocardiography.RESULTS: Women with angina pectoris had significantly longer QTc intervals (429±20ms) and increased MCS (IQR) (0.73 [0.64-0.80]) compared with the controls (419±20ms) and (0.63 [(0.53-0.73]), respectively (both p<0.001). CFVR was associated with longer QTc interval (p=0.02), but the association was attenuated after multivariable adjustment (p=0.08).CONCLUSION: This study suggests that women with angina pectoris have alterations in T-wave morphology as well as longer QTc interval compared with a reference population. CMD might be an explanation.

AB - OBJECTIVES: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD.METHODS: Women with angina pectoris and no obstructive coronary artery disease (n=138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch. CMD was assessed as a coronary flow velocity reserve (CFVR) by transthoracic echocardiography.RESULTS: Women with angina pectoris had significantly longer QTc intervals (429±20ms) and increased MCS (IQR) (0.73 [0.64-0.80]) compared with the controls (419±20ms) and (0.63 [(0.53-0.73]), respectively (both p<0.001). CFVR was associated with longer QTc interval (p=0.02), but the association was attenuated after multivariable adjustment (p=0.08).CONCLUSION: This study suggests that women with angina pectoris have alterations in T-wave morphology as well as longer QTc interval compared with a reference population. CMD might be an explanation.

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JO - Journal of Electrocardiology

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ER -

Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction

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