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Venous thromboembolism after fast-track unicompartmental knee arthroplasty - A prospective multicentre cohort study of 3927 procedures

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Petersen, Pelle Baggesgaard ; Jørgensen, Christoffer Calov ; Gromov, Kirill ; Kehlet, Henrik ; Lundbeck Foundation Center for Fast-Track Hip and Knee Replacement Collaborative Group (Søren Solgaard, Jens Bagger members). / Venous thromboembolism after fast-track unicompartmental knee arthroplasty - A prospective multicentre cohort study of 3927 procedures. In: Thrombosis Research. 2020 ; Vol. 195. pp. 81-86.

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@article{4c4727dd1b3542379ccbf8b1b3337b3f,
title = "Venous thromboembolism after fast-track unicompartmental knee arthroplasty - A prospective multicentre cohort study of 3927 procedures",
abstract = "INTRODUCTION: Unicompartmental knee arthroplasty (UKA) has increased due to potential favourable complication rates when compared to total knee arthroplasty (TKA). Although venous thromboembolism (VTE) is a well-documented complication after TKA limited data is available after UKA and mostly presented as secondary findings in observational comparisons to TKA. There is a lack of fast-track UKA VTE studies and no guidelines on thromboprophylaxis. Consequently, we described the 90-day incidence of VTE after UKA within a multicentre fast-track collaboration.MATERIALS AND METHODS: We used an observational cohort study design from 8 dedicated fast-track centres with prospective collection of preoperative risk-factors, complete follow-up on length of stay (LOS), 90-day readmissions and mortality from the Danish National Patient Registry and analysis of health records if LOS > 2 days or an ICD-10 code of VTE. Due to limited events we refrained from analysis of independent risk-factors.RESULTS: In 3927 procedures (46.1% males, mean age 66.2 (SD 9.4) years) median LOS was 1 [IQR 0-1] day and 7.5% had LOS > 2 days. The 90-day incidence of VTE was 16 (0.41%) and 14 (0.37%) when excluding preoperatively anticoagulated patients. There were 5 (0.13%) pulmonary embolisms and 11 (0.28%) deep-vein thrombosis after median 18 [11.75-35.25] days. 90-day mortality was 3 (0.08%) with no fatal PE or initial postoperative VTE.CONCLUSIONS: The 90-day incidence of VTE after fast-track UKA was 0.41% (0.37% when excluding preoperatively anticoagulated patients), which is comparable to reports of 0.39% VTEs after fast-track TKA in the same departments. Investigations on risk-factors are needed for optimizing thromboprophylaxis.",
author = "Petersen, {Pelle Baggesgaard} and J{\o}rgensen, {Christoffer Calov} and Kirill Gromov and Henrik Kehlet and {Lundbeck Foundation Center for Fast-Track Hip and Knee Replacement Collaborative Group (S{\o}ren Solgaard, Jens Bagger members)} and S{\o}ren Solgaard and Jens Bagger",
note = "Copyright {\textcopyright} 2020 Elsevier Ltd. All rights reserved.",
year = "2020",
month = nov,
day = "1",
doi = "10.1016/j.thromres.2020.07.002",
language = "English",
volume = "195",
pages = "81--86",
journal = "Thrombosis Research",
issn = "0049-3848",
publisher = "Pergamon",

}

RIS

TY - JOUR

T1 - Venous thromboembolism after fast-track unicompartmental knee arthroplasty - A prospective multicentre cohort study of 3927 procedures

AU - Petersen, Pelle Baggesgaard

AU - Jørgensen, Christoffer Calov

AU - Gromov, Kirill

AU - Kehlet, Henrik

AU - Lundbeck Foundation Center for Fast-Track Hip and Knee Replacement Collaborative Group (Søren Solgaard, Jens Bagger members)

A2 - Solgaard, Søren

A2 - Bagger, Jens

N1 - Copyright © 2020 Elsevier Ltd. All rights reserved.

PY - 2020/11/1

Y1 - 2020/11/1

N2 - INTRODUCTION: Unicompartmental knee arthroplasty (UKA) has increased due to potential favourable complication rates when compared to total knee arthroplasty (TKA). Although venous thromboembolism (VTE) is a well-documented complication after TKA limited data is available after UKA and mostly presented as secondary findings in observational comparisons to TKA. There is a lack of fast-track UKA VTE studies and no guidelines on thromboprophylaxis. Consequently, we described the 90-day incidence of VTE after UKA within a multicentre fast-track collaboration.MATERIALS AND METHODS: We used an observational cohort study design from 8 dedicated fast-track centres with prospective collection of preoperative risk-factors, complete follow-up on length of stay (LOS), 90-day readmissions and mortality from the Danish National Patient Registry and analysis of health records if LOS > 2 days or an ICD-10 code of VTE. Due to limited events we refrained from analysis of independent risk-factors.RESULTS: In 3927 procedures (46.1% males, mean age 66.2 (SD 9.4) years) median LOS was 1 [IQR 0-1] day and 7.5% had LOS > 2 days. The 90-day incidence of VTE was 16 (0.41%) and 14 (0.37%) when excluding preoperatively anticoagulated patients. There were 5 (0.13%) pulmonary embolisms and 11 (0.28%) deep-vein thrombosis after median 18 [11.75-35.25] days. 90-day mortality was 3 (0.08%) with no fatal PE or initial postoperative VTE.CONCLUSIONS: The 90-day incidence of VTE after fast-track UKA was 0.41% (0.37% when excluding preoperatively anticoagulated patients), which is comparable to reports of 0.39% VTEs after fast-track TKA in the same departments. Investigations on risk-factors are needed for optimizing thromboprophylaxis.

AB - INTRODUCTION: Unicompartmental knee arthroplasty (UKA) has increased due to potential favourable complication rates when compared to total knee arthroplasty (TKA). Although venous thromboembolism (VTE) is a well-documented complication after TKA limited data is available after UKA and mostly presented as secondary findings in observational comparisons to TKA. There is a lack of fast-track UKA VTE studies and no guidelines on thromboprophylaxis. Consequently, we described the 90-day incidence of VTE after UKA within a multicentre fast-track collaboration.MATERIALS AND METHODS: We used an observational cohort study design from 8 dedicated fast-track centres with prospective collection of preoperative risk-factors, complete follow-up on length of stay (LOS), 90-day readmissions and mortality from the Danish National Patient Registry and analysis of health records if LOS > 2 days or an ICD-10 code of VTE. Due to limited events we refrained from analysis of independent risk-factors.RESULTS: In 3927 procedures (46.1% males, mean age 66.2 (SD 9.4) years) median LOS was 1 [IQR 0-1] day and 7.5% had LOS > 2 days. The 90-day incidence of VTE was 16 (0.41%) and 14 (0.37%) when excluding preoperatively anticoagulated patients. There were 5 (0.13%) pulmonary embolisms and 11 (0.28%) deep-vein thrombosis after median 18 [11.75-35.25] days. 90-day mortality was 3 (0.08%) with no fatal PE or initial postoperative VTE.CONCLUSIONS: The 90-day incidence of VTE after fast-track UKA was 0.41% (0.37% when excluding preoperatively anticoagulated patients), which is comparable to reports of 0.39% VTEs after fast-track TKA in the same departments. Investigations on risk-factors are needed for optimizing thromboprophylaxis.

U2 - 10.1016/j.thromres.2020.07.002

DO - 10.1016/j.thromres.2020.07.002

M3 - Journal article

C2 - 32673960

VL - 195

SP - 81

EP - 86

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

ER -

ID: 60406092