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Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study

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Harvard

Chowdhury, MM, Tarkin, JM, Albaghdadi, MS, Evans, NR, Le, EPV, Berrett, TB, Sadat, U, Joshi, FR, Warburton, EA, Buscombe, JR, Hayes, PD, Dweck, MR, Newby, DE, Rudd, JHF & Coughlin, PA 2020, 'Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study', JACC. Cardiovascular imaging, vol. 13, no. 4, pp. 1008-1017. https://doi.org/10.1016/j.jcmg.2019.03.031

APA

Chowdhury, M. M., Tarkin, J. M., Albaghdadi, M. S., Evans, N. R., Le, E. P. V., Berrett, T. B., Sadat, U., Joshi, F. R., Warburton, E. A., Buscombe, J. R., Hayes, P. D., Dweck, M. R., Newby, D. E., Rudd, J. H. F., & Coughlin, P. A. (2020). Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study. JACC. Cardiovascular imaging, 13(4), 1008-1017. https://doi.org/10.1016/j.jcmg.2019.03.031

CBE

Chowdhury MM, Tarkin JM, Albaghdadi MS, Evans NR, Le EPV, Berrett TB, Sadat U, Joshi FR, Warburton EA, Buscombe JR, Hayes PD, Dweck MR, Newby DE, Rudd JHF, Coughlin PA. 2020. Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study. JACC. Cardiovascular imaging. 13(4):1008-1017. https://doi.org/10.1016/j.jcmg.2019.03.031

MLA

Vancouver

Author

Chowdhury, Mohammed M ; Tarkin, Jason M ; Albaghdadi, Mazen S ; Evans, Nicholas R ; Le, Elizabeth P V ; Berrett, Thomas B ; Sadat, Umar ; Joshi, Francis R ; Warburton, Elizabeth A ; Buscombe, John R ; Hayes, Paul D ; Dweck, Marc R ; Newby, David E ; Rudd, James H F ; Coughlin, Patrick A. / Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease : A Prospective Clinical Study. In: JACC. Cardiovascular imaging. 2020 ; Vol. 13, No. 4. pp. 1008-1017.

Bibtex

@article{eda47bd3c37347f4900f7017bc518c22,
title = "Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study",
abstract = "OBJECTIVES: This study determined whether in vivo positron emission tomography (PET) of arterial inflammation (18F-fluorodeoxyglucose [18F-FDG]) or microcalcification (18F-sodium fluoride [18F-NaF]) could predict restenosis following PTA.BACKGROUND: Restenosis following lower limb percutaneous transluminal angioplasty (PTA) is common, unpredictable, and challenging to treat. Currently, it is impossible to predict which patient will suffer from restenosis following angioplasty.METHODS: In this prospective observational cohort study, 50 patients with symptomatic peripheral arterial disease underwent 18F-FDG and 18F-NaF PET/computed tomography (CT) imaging of the superficial femoral artery before and 6 weeks after angioplasty. The primary outcome was arterial restenosis at 12 months.RESULTS: Forty subjects completed the study protocol with 14 patients (35%) reaching the primary outcome of restenosis. The baseline activities of femoral arterial inflammation (18F-FDG tissue-to-background ratio [TBR] 2.43 [interquartile range (IQR): 2.29 to 2.61] vs. 1.63 [IQR: 1.52 to 1.78]; p < 0.001) and microcalcification (18F-NaF TBR 2.61 [IQR: 2.50 to 2.77] vs. 1.69 [IQR: 1.54 to 1.77]; p < 0.001) were higher in patients who developed restenosis. The predictive value of both 18F-FDG (cut-off TBRmax value of 1.98) and 18F-NaF (cut-off TBRmax value of 2.11) uptake demonstrated excellent discrimination in predicting 1-year restenosis (Kaplan Meier estimator, log-rank p < 0.001).CONCLUSIONS: Baseline and persistent femoral arterial inflammation and micro-calcification are associated with restenosis following lower limb PTA. For the first time, we describe a method of identifying complex metabolically active plaques and patients at risk of restenosis that has the potential to select patients for intervention and to serve as a biomarker to test novel interventions to prevent restenosis.",
keywords = "F-fluorodeoxyglucose, F-sodium fluoride, atherosclerosis, computed tomography, peripheral arterial disease, positron emission tomography, restenosis",
author = "Chowdhury, {Mohammed M} and Tarkin, {Jason M} and Albaghdadi, {Mazen S} and Evans, {Nicholas R} and Le, {Elizabeth P V} and Berrett, {Thomas B} and Umar Sadat and Joshi, {Francis R} and Warburton, {Elizabeth A} and Buscombe, {John R} and Hayes, {Paul D} and Dweck, {Marc R} and Newby, {David E} and Rudd, {James H F} and Coughlin, {Patrick A}",
note = "Copyright {\textcopyright} 2020 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = apr,
doi = "10.1016/j.jcmg.2019.03.031",
language = "English",
volume = "13",
pages = "1008--1017",
journal = "JACC: Cardiovascular Imaging",
issn = "1936-878X",
publisher = "Elsevier Inc",
number = "4",

}

RIS

TY - JOUR

T1 - Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease

T2 - A Prospective Clinical Study

AU - Chowdhury, Mohammed M

AU - Tarkin, Jason M

AU - Albaghdadi, Mazen S

AU - Evans, Nicholas R

AU - Le, Elizabeth P V

AU - Berrett, Thomas B

AU - Sadat, Umar

AU - Joshi, Francis R

AU - Warburton, Elizabeth A

AU - Buscombe, John R

AU - Hayes, Paul D

AU - Dweck, Marc R

AU - Newby, David E

AU - Rudd, James H F

AU - Coughlin, Patrick A

N1 - Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2020/4

Y1 - 2020/4

N2 - OBJECTIVES: This study determined whether in vivo positron emission tomography (PET) of arterial inflammation (18F-fluorodeoxyglucose [18F-FDG]) or microcalcification (18F-sodium fluoride [18F-NaF]) could predict restenosis following PTA.BACKGROUND: Restenosis following lower limb percutaneous transluminal angioplasty (PTA) is common, unpredictable, and challenging to treat. Currently, it is impossible to predict which patient will suffer from restenosis following angioplasty.METHODS: In this prospective observational cohort study, 50 patients with symptomatic peripheral arterial disease underwent 18F-FDG and 18F-NaF PET/computed tomography (CT) imaging of the superficial femoral artery before and 6 weeks after angioplasty. The primary outcome was arterial restenosis at 12 months.RESULTS: Forty subjects completed the study protocol with 14 patients (35%) reaching the primary outcome of restenosis. The baseline activities of femoral arterial inflammation (18F-FDG tissue-to-background ratio [TBR] 2.43 [interquartile range (IQR): 2.29 to 2.61] vs. 1.63 [IQR: 1.52 to 1.78]; p < 0.001) and microcalcification (18F-NaF TBR 2.61 [IQR: 2.50 to 2.77] vs. 1.69 [IQR: 1.54 to 1.77]; p < 0.001) were higher in patients who developed restenosis. The predictive value of both 18F-FDG (cut-off TBRmax value of 1.98) and 18F-NaF (cut-off TBRmax value of 2.11) uptake demonstrated excellent discrimination in predicting 1-year restenosis (Kaplan Meier estimator, log-rank p < 0.001).CONCLUSIONS: Baseline and persistent femoral arterial inflammation and micro-calcification are associated with restenosis following lower limb PTA. For the first time, we describe a method of identifying complex metabolically active plaques and patients at risk of restenosis that has the potential to select patients for intervention and to serve as a biomarker to test novel interventions to prevent restenosis.

AB - OBJECTIVES: This study determined whether in vivo positron emission tomography (PET) of arterial inflammation (18F-fluorodeoxyglucose [18F-FDG]) or microcalcification (18F-sodium fluoride [18F-NaF]) could predict restenosis following PTA.BACKGROUND: Restenosis following lower limb percutaneous transluminal angioplasty (PTA) is common, unpredictable, and challenging to treat. Currently, it is impossible to predict which patient will suffer from restenosis following angioplasty.METHODS: In this prospective observational cohort study, 50 patients with symptomatic peripheral arterial disease underwent 18F-FDG and 18F-NaF PET/computed tomography (CT) imaging of the superficial femoral artery before and 6 weeks after angioplasty. The primary outcome was arterial restenosis at 12 months.RESULTS: Forty subjects completed the study protocol with 14 patients (35%) reaching the primary outcome of restenosis. The baseline activities of femoral arterial inflammation (18F-FDG tissue-to-background ratio [TBR] 2.43 [interquartile range (IQR): 2.29 to 2.61] vs. 1.63 [IQR: 1.52 to 1.78]; p < 0.001) and microcalcification (18F-NaF TBR 2.61 [IQR: 2.50 to 2.77] vs. 1.69 [IQR: 1.54 to 1.77]; p < 0.001) were higher in patients who developed restenosis. The predictive value of both 18F-FDG (cut-off TBRmax value of 1.98) and 18F-NaF (cut-off TBRmax value of 2.11) uptake demonstrated excellent discrimination in predicting 1-year restenosis (Kaplan Meier estimator, log-rank p < 0.001).CONCLUSIONS: Baseline and persistent femoral arterial inflammation and micro-calcification are associated with restenosis following lower limb PTA. For the first time, we describe a method of identifying complex metabolically active plaques and patients at risk of restenosis that has the potential to select patients for intervention and to serve as a biomarker to test novel interventions to prevent restenosis.

KW - F-fluorodeoxyglucose

KW - F-sodium fluoride

KW - atherosclerosis

KW - computed tomography

KW - peripheral arterial disease

KW - positron emission tomography

KW - restenosis

U2 - 10.1016/j.jcmg.2019.03.031

DO - 10.1016/j.jcmg.2019.03.031

M3 - Journal article

C2 - 31202739

VL - 13

SP - 1008

EP - 1017

JO - JACC: Cardiovascular Imaging

JF - JACC: Cardiovascular Imaging

SN - 1936-878X

IS - 4

ER -

ID: 59127186