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Various functions of PBMC from colon cancer patients are not decreased compared to healthy blood donors.

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  1. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

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  2. Sequential radioimmunotherapy with 177Lu- and 211At-labeled monoclonal antibody BR96 in a syngeneic rat colon carcinoma model

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  3. Comparison of (211)At-PRIT and (211)At-RIT of Ovarian Microtumors in a Nude Mouse Model

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  4. Evaluation of effects on the peritoneum after intraperitoneal α-radioimmunotherapy with (211)At

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  5. Intraperitoneal alpha-radioimmunotherapy in mice using different specific activities

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  1. Triage for selection to colonoscopy?

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  2. Clean Colorectum at Diagnostic Colonoscopy: Subsequent Detection of Extracolonic Malignancies by Plasma Protein Biomarkers?

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  3. Circulating cell-free nucleosomes as biomarkers for early detection of colorectal cancer

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The immune surveillance hypothesis suggests impaired immune responses to participate in development of cancer. This may partly be due to increased amounts of PGE2 and histamine, which inhibit cellular immunity. These effects are mediated by cAMP, which is increased and thereby may down-regulate IL-2 and its receptor proteins in T helper cells. The proliferative responses and IL-2 synthesis of PBMC have earlier been shown to be reduced in patients with colon cancer. Recently immune modulating agents have been demonstrated to increase the proliferative response of PBMC in vitro, probably by inhibition of adenylate cyclase activity and induction of IL-2 mRNA expression. We have therefore studied the proliferative responses of PBMC from colon cancer patients to PWM and tested the effect of immune modulating agents, such as Serotonin, Sumatriptan, and Buspirone on these PBMC. We found no difference in levels of intracellular cAMP, IL-2 mRNA expression, IL-2R mRNA expression, or proliferative responses of PBMC from colon cancer patients compared to healthy blood donors. There was no effect of the immune modulating agents on PBMC from colon cancer patients.
Translated title of the contributionVarious functions of PBMC from colon cancer patients are not decreased compared to healthy blood donors.
Original languageEnglish
JournalCancer Biotherapy & Radiopharmaceuticals
Volume12
Issue number2
Pages (from-to)73-78
Number of pages6
ISSN1084-9785
Publication statusPublished - 1997

ID: 32503690