Variation in the purinergic P2RX(7) receptor gene and schizophrenia

Thomas Folkmann Hansen; Klaus D Jakobsen; Mogens Fenger; Jimmi Nielsen; Karoline Krane; Anders Fink-Jensen; Henrik Lublin; Henrik Ullum; Sally Timm; August G Wang; Niklas Rye Jørgensen; Thomas Werge

doi:10.1016/j.schres.2008.05.026

Variation in the purinergic P2RX(7) receptor gene and schizophrenia

Thomas Folkmann Hansen, Klaus D Jakobsen, Mogens Fenger, Jimmi Nielsen, Karoline Krane, Anders Fink-Jensen, Henrik Lublin, Henrik Ullum, Sally Timm, August G Wang, Niklas Rye Jørgensen, Thomas Werge

22 Citations (Scopus)

Abstract

INTRODUCTION: The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia. METHODS: Nine functionally characterised variants in P2RX(7) were genotyped in 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls. RESULTS: We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding. CONCLUSION: P2XR(7) was not associated with schizophrenia in this study.

Original language	English
Journal	Schizophrenia Research
Volume	104
Issue number	1-3
Pages (from-to)	146-52
Number of pages	6
DOIs	https://doi.org/10.1016/j.schres.2008.05.026
Publication status	Published - 2008

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10.1016/j.schres.2008.05.026

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title = "Variation in the purinergic P2RX(7) receptor gene and schizophrenia",

abstract = "INTRODUCTION: The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia. METHODS: Nine functionally characterised variants in P2RX(7) were genotyped in 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls. RESULTS: We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding. CONCLUSION: P2XR(7) was not associated with schizophrenia in this study.",

author = "Hansen, {Thomas Folkmann} and Jakobsen, {Klaus D} and Mogens Fenger and Jimmi Nielsen and Karoline Krane and Anders Fink-Jensen and Henrik Lublin and Henrik Ullum and Sally Timm and Wang, {August G} and J{\o}rgensen, {Niklas Rye} and Thomas Werge",

note = "Keywords: Adult; Aged; Aged, 80 and over; Alleles; Denmark; European Continental Ancestry Group; Female; Genetic Variation; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Purinergic P2; Schizophrenia; Young Adult",

year = "2008",

doi = "10.1016/j.schres.2008.05.026",

language = "English",

volume = "104",

pages = "146--52",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier BV",

number = "1-3",

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TY - JOUR

T1 - Variation in the purinergic P2RX(7) receptor gene and schizophrenia

AU - Hansen, Thomas Folkmann

AU - Jakobsen, Klaus D

AU - Fenger, Mogens

AU - Nielsen, Jimmi

AU - Krane, Karoline

AU - Fink-Jensen, Anders

AU - Lublin, Henrik

AU - Ullum, Henrik

AU - Timm, Sally

AU - Wang, August G

AU - Jørgensen, Niklas Rye

AU - Werge, Thomas

N1 - Keywords: Adult; Aged; Aged, 80 and over; Alleles; Denmark; European Continental Ancestry Group; Female; Genetic Variation; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Purinergic P2; Schizophrenia; Young Adult

PY - 2008

Y1 - 2008

N2 - INTRODUCTION: The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia. METHODS: Nine functionally characterised variants in P2RX(7) were genotyped in 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls. RESULTS: We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding. CONCLUSION: P2XR(7) was not associated with schizophrenia in this study.

AB - INTRODUCTION: The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia. METHODS: Nine functionally characterised variants in P2RX(7) were genotyped in 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls. RESULTS: We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding. CONCLUSION: P2XR(7) was not associated with schizophrenia in this study.

U2 - 10.1016/j.schres.2008.05.026

DO - 10.1016/j.schres.2008.05.026

M3 - Journal article

C2 - 18614336

VL - 104

SP - 146

EP - 152

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1-3

ER -

Variation in the purinergic P2RX(7) receptor gene and schizophrenia

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