Variation in 5' promoter region of the APOE gene contributes to predicting ischemic heart disease (IHD) in the population at large: the Copenhagen City Heart Study

J H Stengård; R Frikke-Schmidt; A Tybjaerg-Hansen; B G Nordestgaard; C F Sing

doi:10.1111/j.1469-1809.2007.00370.x

Variation in 5' promoter region of the APOE gene contributes to predicting ischemic heart disease (IHD) in the population at large: the Copenhagen City Heart Study

J H Stengård, R Frikke-Schmidt, A Tybjaerg-Hansen, B G Nordestgaard, C F Sing

10 Citations (Scopus)

Abstract

The objective of this study was to evaluate whether an increased hazard of developing ischemic heart disease (IHD) is associated with any of the three genotypes A560T832/A560T832, A560T832/A560G832 and A560T832/T560T832, defined by variations in two non-coding SNPs in the 5' promoter region of the apolipoprotein E (APOE) gene. These genotypes were selected because they distinguished between high and low levels of HDL-C, TG and/or T-C in our earlier study of multiple samples defined by gender and population. We found a significant increase (p<0.05) in the hazard of IHD in females with the A560T832/T560T832 genotype that remained significant after fitting the effects of dyslipidemia, other established risk factors, and the structural isoform variations of the ApoE molecule. We discuss why this statistically significant genetic predictor may not be an appropriate screening test for IHD in the Danish population at large.

Original language	English
Journal	Annals of human genetics
Volume	71
Issue number	Pt 6
Pages (from-to)	762-71
Number of pages	10
ISSN	0003-4800
DOIs	https://doi.org/10.1111/j.1469-1809.2007.00370.x
Publication status	Published - Nov 2007
Externally published	Yes

Keywords

Adult
Aged
Aged, 80 and over
Apolipoproteins E/genetics
Cholesterol, HDL/blood
Denmark
Female
Genetic Predisposition to Disease
Genetic Testing
Genetic Variation
Genotype
Humans
Male
Middle Aged
Models, Genetic
Myocardial Ischemia/blood
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Prospective Studies
Risk Factors
Sex Factors
Triglycerides/blood

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10.1111/j.1469-1809.2007.00370.x

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Variation in 5' promoter region of the APOE gene contributes to predicting ischemic heart disease (IHD) in the population at large: the Copenhagen City Heart Study. / Stengård, J H; Frikke-Schmidt, R; Tybjaerg-Hansen, A et al.
In: Annals of human genetics, Vol. 71, No. Pt 6, 11.2007, p. 762-71.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Variation in 5' promoter region of the APOE gene contributes to predicting ischemic heart disease (IHD) in the population at large: the Copenhagen City Heart Study",

abstract = "The objective of this study was to evaluate whether an increased hazard of developing ischemic heart disease (IHD) is associated with any of the three genotypes A560T832/A560T832, A560T832/A560G832 and A560T832/T560T832, defined by variations in two non-coding SNPs in the 5' promoter region of the apolipoprotein E (APOE) gene. These genotypes were selected because they distinguished between high and low levels of HDL-C, TG and/or T-C in our earlier study of multiple samples defined by gender and population. We found a significant increase (p<0.05) in the hazard of IHD in females with the A560T832/T560T832 genotype that remained significant after fitting the effects of dyslipidemia, other established risk factors, and the structural isoform variations of the ApoE molecule. We discuss why this statistically significant genetic predictor may not be an appropriate screening test for IHD in the Danish population at large.",

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language = "English",

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T1 - Variation in 5' promoter region of the APOE gene contributes to predicting ischemic heart disease (IHD) in the population at large

T2 - the Copenhagen City Heart Study

AU - Stengård, J H

AU - Frikke-Schmidt, R

AU - Tybjaerg-Hansen, A

AU - Nordestgaard, B G

AU - Sing, C F

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N2 - The objective of this study was to evaluate whether an increased hazard of developing ischemic heart disease (IHD) is associated with any of the three genotypes A560T832/A560T832, A560T832/A560G832 and A560T832/T560T832, defined by variations in two non-coding SNPs in the 5' promoter region of the apolipoprotein E (APOE) gene. These genotypes were selected because they distinguished between high and low levels of HDL-C, TG and/or T-C in our earlier study of multiple samples defined by gender and population. We found a significant increase (p<0.05) in the hazard of IHD in females with the A560T832/T560T832 genotype that remained significant after fitting the effects of dyslipidemia, other established risk factors, and the structural isoform variations of the ApoE molecule. We discuss why this statistically significant genetic predictor may not be an appropriate screening test for IHD in the Danish population at large.

AB - The objective of this study was to evaluate whether an increased hazard of developing ischemic heart disease (IHD) is associated with any of the three genotypes A560T832/A560T832, A560T832/A560G832 and A560T832/T560T832, defined by variations in two non-coding SNPs in the 5' promoter region of the apolipoprotein E (APOE) gene. These genotypes were selected because they distinguished between high and low levels of HDL-C, TG and/or T-C in our earlier study of multiple samples defined by gender and population. We found a significant increase (p<0.05) in the hazard of IHD in females with the A560T832/T560T832 genotype that remained significant after fitting the effects of dyslipidemia, other established risk factors, and the structural isoform variations of the ApoE molecule. We discuss why this statistically significant genetic predictor may not be an appropriate screening test for IHD in the Danish population at large.

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KW - Aged

KW - Aged, 80 and over

KW - Apolipoproteins E/genetics

KW - Cholesterol, HDL/blood

KW - Denmark

KW - Female

KW - Genetic Predisposition to Disease

KW - Genetic Testing

KW - Genetic Variation

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Models, Genetic

KW - Myocardial Ischemia/blood

KW - Polymorphism, Single Nucleotide

KW - Promoter Regions, Genetic

KW - Prospective Studies

KW - Risk Factors

KW - Sex Factors

KW - Triglycerides/blood

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DO - 10.1111/j.1469-1809.2007.00370.x

M3 - Journal article

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SN - 0003-4800

VL - 71

SP - 762

EP - 771

JO - Annals of human genetics

JF - Annals of human genetics

IS - Pt 6

ER -

Variation in 5' promoter region of the APOE gene contributes to predicting ischemic heart disease (IHD) in the population at large: the Copenhagen City Heart Study

Abstract

Keywords

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