Variability of monthly nitrogen multiple-breath washout during one year in children with cystic fibrosis

Kent Green; Thomas Kongstad; Marianne Skov; Frederik Buchvald; Susanne Rosthøj; Jacob Louis Marott; Per Gustafsson; Tacjana Pressler; Kim Gjerum Nielsen

doi:10.1016/j.jcf.2017.11.007

Variability of monthly nitrogen multiple-breath washout during one year in children with cystic fibrosis

Kent Green, Thomas Kongstad, Marianne Skov, Frederik Buchvald, Susanne Rosthøj, Jacob Louis Marott, Per Gustafsson, Tacjana Pressler, Kim Gjerum Nielsen

25 Citations (Scopus)

Abstract

BACKGROUND: Knowledge of between-session variability of nitrogen multiple-breath washout (N2MBW) indices is crucial when designing longitudinal interventional studies and in disease monitoring using N2MBW as end-point. Such information is currently sparse.

METHODS: Monthly triplets of N2MBW were prospectively obtained from 14 children with CF during one year. Linear mixed models were used to analyze variability. Our aim was to assess between-session variability of N2MBW indices from repeated measurements and compare LCI derived from different software packages currently in use (TestPoint® vs. Spiroware®).

RESULTS: Baseline LCI (median; range) was 9.37 (6.82; 12.08). Between-session differences in LCI measurements were up to 25%. Intra Class Correlation-Coefficient was 0.82. There was no systematic difference between LCI measurements derived from the two software packages (p=0.18); however, variability was significantly higher using Spiroware®.

CONCLUSIONS: We report between-session variability of LCI using N2MBW in school-age children and adolescents with CF. LCI changes exceeding 25% may be considered clinically relevant. TestPoint® and Spiroware® can be used interchangeably in longitudinal studies.

Original language	English
Journal	Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Volume	17
Issue number	2
Pages (from-to)	242-48
ISSN	1569-1993
DOIs	https://doi.org/10.1016/j.jcf.2017.11.007
Publication status	Published - 2018

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Journal Article

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10.1016/j.jcf.2017.11.007

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Green, K., Kongstad, T., Skov, M., Buchvald, F., Rosthøj, S., Marott, J. L., Gustafsson, P., Pressler, T., & Nielsen, K. G. (2018). Variability of monthly nitrogen multiple-breath washout during one year in children with cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 17(2), 242-48. https://doi.org/10.1016/j.jcf.2017.11.007

Variability of monthly nitrogen multiple-breath washout during one year in children with cystic fibrosis. / Green, Kent; Kongstad, Thomas; Skov, Marianne et al.
In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, Vol. 17, No. 2, 2018, p. 242-48.

Research output: Contribution to journal › Journal article › Research › peer-review

Green, K, Kongstad, T, Skov, M , Buchvald, F, Rosthøj, S, Marott, JL, Gustafsson, P, Pressler, T & Nielsen, KG 2018, 'Variability of monthly nitrogen multiple-breath washout during one year in children with cystic fibrosis', Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, vol. 17, no. 2, pp. 242-48. https://doi.org/10.1016/j.jcf.2017.11.007

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T1 - Variability of monthly nitrogen multiple-breath washout during one year in children with cystic fibrosis

AU - Green, Kent

AU - Kongstad, Thomas

AU - Skov, Marianne

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AU - Rosthøj, Susanne

AU - Marott, Jacob Louis

AU - Gustafsson, Per

AU - Pressler, Tacjana

AU - Nielsen, Kim Gjerum

PY - 2018

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N2 - BACKGROUND: Knowledge of between-session variability of nitrogen multiple-breath washout (N2MBW) indices is crucial when designing longitudinal interventional studies and in disease monitoring using N2MBW as end-point. Such information is currently sparse.METHODS: Monthly triplets of N2MBW were prospectively obtained from 14 children with CF during one year. Linear mixed models were used to analyze variability. Our aim was to assess between-session variability of N2MBW indices from repeated measurements and compare LCI derived from different software packages currently in use (TestPoint® vs. Spiroware®).RESULTS: Baseline LCI (median; range) was 9.37 (6.82; 12.08). Between-session differences in LCI measurements were up to 25%. Intra Class Correlation-Coefficient was 0.82. There was no systematic difference between LCI measurements derived from the two software packages (p=0.18); however, variability was significantly higher using Spiroware®.CONCLUSIONS: We report between-session variability of LCI using N2MBW in school-age children and adolescents with CF. LCI changes exceeding 25% may be considered clinically relevant. TestPoint® and Spiroware® can be used interchangeably in longitudinal studies.

AB - BACKGROUND: Knowledge of between-session variability of nitrogen multiple-breath washout (N2MBW) indices is crucial when designing longitudinal interventional studies and in disease monitoring using N2MBW as end-point. Such information is currently sparse.METHODS: Monthly triplets of N2MBW were prospectively obtained from 14 children with CF during one year. Linear mixed models were used to analyze variability. Our aim was to assess between-session variability of N2MBW indices from repeated measurements and compare LCI derived from different software packages currently in use (TestPoint® vs. Spiroware®).RESULTS: Baseline LCI (median; range) was 9.37 (6.82; 12.08). Between-session differences in LCI measurements were up to 25%. Intra Class Correlation-Coefficient was 0.82. There was no systematic difference between LCI measurements derived from the two software packages (p=0.18); however, variability was significantly higher using Spiroware®.CONCLUSIONS: We report between-session variability of LCI using N2MBW in school-age children and adolescents with CF. LCI changes exceeding 25% may be considered clinically relevant. TestPoint® and Spiroware® can be used interchangeably in longitudinal studies.

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JO - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

JF - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

IS - 2

ER -

Variability of monthly nitrogen multiple-breath washout during one year in children with cystic fibrosis

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