Vancomycin decreases insulin sensitivity and is associated with alterations in intestinal microbiota and bile acid composition in obese subjects with metabolic syndrome

Anne Vrieze; Carolien Out; Susana Fuentes; Lisanne Jonker; Isaie Reuling; Ruud S Kootte; E van Nood; Frits Holleman; Max Knaapen; Johannes A Romijn; Maarten R Soeters; Ellen E Blaak; Geesje M Dallinga-Thie; Dorien Reijnders; Mariëtte T Ackermans; Mireille J Serlie; Filip K Knop; Jens J Holst; Claude van der Ley; Ido P Kema; Erwin G Zoetendal; Willem M de Vos; Joost B L Hoekstra; E S Stroes; Albert K Groen; Max Nieuwdorp

doi:10.1016/j.jhep.2013.11.034

Vancomycin decreases insulin sensitivity and is associated with alterations in intestinal microbiota and bile acid composition in obese subjects with metabolic syndrome

Anne Vrieze, Carolien Out, Susana Fuentes, Lisanne Jonker, Isaie Reuling, Ruud S Kootte, E van Nood, Frits Holleman, Max Knaapen, Johannes A Romijn, Maarten R Soeters, Ellen E Blaak, Geesje M Dallinga-Thie, Dorien Reijnders, Mariëtte T Ackermans, Mireille J Serlie, Filip K Knop, Jens J Holst, Claude van der Ley, Ido P KemaErwin G Zoetendal, Willem M de Vos, Joost B L Hoekstra, E S Stroes, Albert K Groen, Max Nieuwdorp

512 Citations (Scopus)

Abstract

Obesity has been associated with changes in the composition and function of the intestinal microbiota. Modulation of the microbiota by antibiotics also alters bile acid and glucose metabolism in mice. Hence, we hypothesized that short term administration of oral antibiotics in humans would affect fecal microbiota composition and subsequently bile acid and glucose metabolism.

Original language	English
Journal	Journal of Hepatology
Volume	60
Issue number	4
Pages (from-to)	824-831
Number of pages	8
ISSN	0168-8278
DOIs	https://doi.org/10.1016/j.jhep.2013.11.034
Publication status	Published - Apr 2014

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10.1016/j.jhep.2013.11.034

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Vrieze, A., Out, C., Fuentes, S., Jonker, L., Reuling, I., Kootte, R. S., van Nood, E., Holleman, F., Knaapen, M., Romijn, J. A., Soeters, M. R., Blaak, E. E., Dallinga-Thie, G. M., Reijnders, D., Ackermans, M. T., Serlie, M. J., Knop, F. K., Holst, J. J., Ley, C. V. D., ... Nieuwdorp, M. (2014). Vancomycin decreases insulin sensitivity and is associated with alterations in intestinal microbiota and bile acid composition in obese subjects with metabolic syndrome. Journal of Hepatology, 60(4), 824-831. https://doi.org/10.1016/j.jhep.2013.11.034

Vancomycin decreases insulin sensitivity and is associated with alterations in intestinal microbiota and bile acid composition in obese subjects with metabolic syndrome. / Vrieze, Anne; Out, Carolien; Fuentes, Susana et al.
In: Journal of Hepatology, Vol. 60, No. 4, 04.2014, p. 824-831.

Research output: Contribution to journal › Journal article › Research › peer-review

Vrieze, A, Out, C, Fuentes, S, Jonker, L, Reuling, I, Kootte, RS, van Nood, E, Holleman, F, Knaapen, M, Romijn, JA, Soeters, MR, Blaak, EE, Dallinga-Thie, GM, Reijnders, D, Ackermans, MT, Serlie, MJ, Knop, FK, Holst, JJ, Ley, CVD, Kema, IP, Zoetendal, EG, de Vos, WM, Hoekstra, JBL, Stroes, ES, Groen, AK & Nieuwdorp, M 2014, 'Vancomycin decreases insulin sensitivity and is associated with alterations in intestinal microbiota and bile acid composition in obese subjects with metabolic syndrome', Journal of Hepatology, vol. 60, no. 4, pp. 824-831. https://doi.org/10.1016/j.jhep.2013.11.034

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title = "Vancomycin decreases insulin sensitivity and is associated with alterations in intestinal microbiota and bile acid composition in obese subjects with metabolic syndrome",

abstract = "Obesity has been associated with changes in the composition and function of the intestinal microbiota. Modulation of the microbiota by antibiotics also alters bile acid and glucose metabolism in mice. Hence, we hypothesized that short term administration of oral antibiotics in humans would affect fecal microbiota composition and subsequently bile acid and glucose metabolism.",

author = "Anne Vrieze and Carolien Out and Susana Fuentes and Lisanne Jonker and Isaie Reuling and Kootte, \{Ruud S\} and \{van Nood\}, E and Frits Holleman and Max Knaapen and Romijn, \{Johannes A\} and Soeters, \{Maarten R\} and Blaak, \{Ellen E\} and Dallinga-Thie, \{Geesje M\} and Dorien Reijnders and Ackermans, \{Mari{\"e}tte T\} and Serlie, \{Mireille J\} and Knop, \{Filip K\} and Holst, \{Jens J\} and Ley, \{Claude van der\} and Kema, \{Ido P\} and Zoetendal, \{Erwin G\} and \{de Vos\}, \{Willem M\} and Hoekstra, \{Joost B L\} and Stroes, \{E S\} and Groen, \{Albert K\} and Max Nieuwdorp",

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year = "2014",

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doi = "10.1016/j.jhep.2013.11.034",

language = "English",

volume = "60",

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T1 - Vancomycin decreases insulin sensitivity and is associated with alterations in intestinal microbiota and bile acid composition in obese subjects with metabolic syndrome

AU - Vrieze, Anne

AU - Out, Carolien

AU - Fuentes, Susana

AU - Jonker, Lisanne

AU - Reuling, Isaie

AU - Kootte, Ruud S

AU - van Nood, E

AU - Holleman, Frits

AU - Knaapen, Max

AU - Romijn, Johannes A

AU - Soeters, Maarten R

AU - Blaak, Ellen E

AU - Dallinga-Thie, Geesje M

AU - Reijnders, Dorien

AU - Ackermans, Mariëtte T

AU - Serlie, Mireille J

AU - Knop, Filip K

AU - Holst, Jens J

AU - Ley, Claude van der

AU - Kema, Ido P

AU - Zoetendal, Erwin G

AU - de Vos, Willem M

AU - Hoekstra, Joost B L

AU - Stroes, E S

AU - Groen, Albert K

AU - Nieuwdorp, Max

PY - 2014/4

Y1 - 2014/4

N2 - Obesity has been associated with changes in the composition and function of the intestinal microbiota. Modulation of the microbiota by antibiotics also alters bile acid and glucose metabolism in mice. Hence, we hypothesized that short term administration of oral antibiotics in humans would affect fecal microbiota composition and subsequently bile acid and glucose metabolism.

AB - Obesity has been associated with changes in the composition and function of the intestinal microbiota. Modulation of the microbiota by antibiotics also alters bile acid and glucose metabolism in mice. Hence, we hypothesized that short term administration of oral antibiotics in humans would affect fecal microbiota composition and subsequently bile acid and glucose metabolism.

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U2 - 10.1016/j.jhep.2013.11.034

DO - 10.1016/j.jhep.2013.11.034

M3 - Journal article

C2 - 24316517

SN - 0168-8278

VL - 60

SP - 824

EP - 831

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 4

ER -

Vancomycin decreases insulin sensitivity and is associated with alterations in intestinal microbiota and bile acid composition in obese subjects with metabolic syndrome

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