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The Capital Region of Denmark - a part of Copenhagen University Hospital

Value of pre- and intraoperative diagnostic methods in suspected glottic neoplasia

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  • Camilla Slot Mehlum
  • Thomas Kjaergaard
  • Ågot Møller Grøntved
  • Nina Munk Lyhne
  • Andreas Peter Schjellerup Jørkov
  • Preben Homøe
  • Jesper Filtenborg Tvedskov
  • Kristian Hveysel Bork
  • Sören Möller
  • Gita Jørgensen
  • Bahareh Bakhshaie Philipsen
  • Christian Godballe
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PURPOSE: To evaluate the individual and combined ability of videostroboscopy (VS), high-speed digital imaging (HSDI), enhanced endoscopy (EE) and saline infusion (SI) to predict neoplasia, defined as glottic precursor lesion (GPL) or T1a glottic cancer, in patients suspected for glottic neoplasia.

METHODS: A nationwide prospective cohort study of patients treated by cordectomy for suspected GPL or T1a glottic cancer from August 1st 2016 to October 31st 2018 was conducted in the five Danish University Departments of Head and Neck surgery. Sensitivity, specificity, negative and positive predictive values, and area under Receiver Operating Curves (AUC-ROC) were calculated with 95% confidence intervals with respect to the histological diagnosis. Logistic regression with an imputation model for missing data was applied.

RESULTS: 261 patients aged 34-91 years participated; 79 (30.3%) with non-neoplasia (i.e., inflammation, papilloma, hyperkeratosis) and 182 (69.7%) neoplasia, hereof 95 (36.4%) with GPL and 87 (33.3%) with T1a glottic cancer. Data from 188 VS, 60 HSDI, 100 preoperative EE, 209 intraoperative EE, and 234 SI were analyzed. In the complete case analysis the AUC-ROC of each diagnostic test was low, but increased when the tests were combined and especially if the combination included EE. However, multinomial logistic regression with imputation showed significant association (p < 0.05) only between age, male gender, and perpendicular vasculature in intraoperative EE, and the endpoint neoplasia.

CONCLUSIONS: Intraoperative EE was the most accurate diagnostic method in detecting neoplasia. The prediction ability of methods applied preoperatively was more limited, but improved when test modalities were combined.

Original languageEnglish
JournalEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Issue number1
Pages (from-to)207-15
Number of pages9
Publication statusPublished - 2020

    Research areas

  • Diagnostic accuracy, Glottic, Neoplasia, Precursor lesion, Premalignant, Precancerous Conditions/diagnosis, Prospective Studies, Area Under Curve, Laryngeal Diseases/diagnosis, Respiratory Mucosa/blood supply, Humans, Middle Aged, Male, Vocal Cords/blood supply, Sensitivity and Specificity, Aged, 80 and over, Adult, Female, Registries, Laryngeal Neoplasms/blood supply, Laryngoscopy/methods, Logistic Models, Preoperative Care, Glottis/blood supply, Intraoperative Care, Aged

ID: 58869077