Value of inflammatory markers for monitoring disease severity and progression in granuloma induced by cosmetic oil injections

OBJECTIVE: Cosmetic oil injections can cause foreign body granulomas, leading to inflammation-driven extrarenal production of activated vitamin D (1,25(OH)2D3) and severe hypercalcemia. This study investigates longitudinal changes in inflammatory markers: interleukin 2 receptor (IL-2R), peptidyl dipeptidase (ACE), and ferritin in patients with oil-induced granuloma.

MATERIALS AND METHODS: 109 male patients were stratified according to baseline calcium status. 28 % had hypercalcemia, and 72 % normocalcemia. Normocalcemic patients were subdivided based on serum parathyroid hormone (PTH) concentrations into suppressed (< 2.0 pmol/L, n = 30) or normal (≥ 2.0 pmol/L, n = 49) concentrations. Blood samples were collected over 48 months and longitudinal changes in inflammatory markers and calcium homeostasis were examined using Pearson correlation and mixed model analyses.

RESULTS: IL-2R, ACE, and ferritin were positively correlated with serum concentration of ionized calcium, while IL-2R was associated with serum 1,25(OH)2D3. In patients with hypercalcemia, IL-2R decreased at 6 (p = 0.041), 24 (p = 0.048), and 36 months (p = 0.035). ACE increased at 48 months (p = 0.008). In patients with normocalcemia and suppressed PTH, IL-2R increased at 24 months (p = 0.021), while serum ferritin increased in patients with normocalcemia and normal PTH at 6 (p = 0.040), 12 (p = 0.008), 24 (p = 0.028), and 48 months (p = 0.005).

CONCLUSIONS: Positive correlations were observed at baseline between ionized calcium concentrations and IL-2R, ionized calcium and ferritin, and 1,25(OH)₂D₃ and IL-2R. Hypercalcemia and suppressed PTH was associated with elevated IL-2R and ferritin concentrations at baseline. Over time, IL-2R and ferritin concentrations decreased in patients with hypercalcemia, some treated with immunomodulatory drugs. IL-2R and ferritin concentrations increased in untreated patients with normocalcemia.