Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Validity and characteristics of patient-evaluated adherence to medication via smartphones in patients with bipolar disorder: exploratory reanalyses on pooled data from the MONARCA I and II trials

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Using big data to advance mental health research

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Autoimmune diseases can be associated with depression

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Evidence on methylphenidate in children and adolescents with ADHD is in fact of 'very low quality'

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Hospital management of self-harm and later risk of suicide and overall mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Dialectical behaviour therapy with skills training seems to be more effective in reducing non-suicidal self-injury

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Automatically generated smartphone data and subjective stress in healthy individuals - a pilot study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Association between Mental Disorders and Subsequent Medical Conditions

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Forecasting Mood in Bipolar Disorder From Smartphone Self-assessments: Hierarchical Bayesian Approach

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Depression under graviditet: et klinisk dilemma

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Hypomania/Mania by DSM-5 definition based on daily smartphone-based patient-reported assessments

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Non-adherence to medication is associated with increased risk of relapse in patients with bipolar disorder (BD).

OBJECTIVES: To (1) validate patient-evaluated adherence to medication measured via smartphones against validated adherence questionnaire; and (2) investigate characteristics for adherence to medication measured via smartphones.

METHODS: Patients with BD (n=117) evaluated adherence to medication daily for 6-9 months via smartphones. The Medication Adherence Rating Scale (MARS) and the Rogers' Empowerment questionnaires were filled out. The 17-item Hamilton Depression Rating Scale, the Young Mania Rating Scale and the Functional Assessment Short Test were clinically rated. Data were collected multiple times per patient. The present study represents exploratory pooled reanalyses of data collected as part of two randomised controlled trials.

FINDINGS: During the study 90.50% of the days were evaluated as 'medication taken', 6.91% as 'medication taken with changes' and 2.59% as 'medication not taken'. Adherence to medication measured via smartphones was valid compared with the MARS (B: -0.049, 95% CI -0.095 to -0.003, p=0.033). Younger age and longer illness duration were significant predictors for non-adherence to medication (model concerning age: B: 0.0039, 95% CI 0.00019 to 0.0076, p=0.040). Decreased affective symptoms measured with smartphone-based patient-reported mood and clinical ratings as well as decreased empowerment were associated with non-adherence.

CONCLUSIONS: Smartphone-based monitoring of adherence to medication was valid compared with validated adherence questionnaire. Younger age and longer illness duration were predictors for non-adherence. Increased empowerment was associated with adherence.

CLINICAL IMPLICATIONS: Using smartphones for empowerment of adherence using patient-reported measures may be helpful in everyday clinical settings.

TRIAL REGISTRATION NUMBER: NCT01446406 and NCT02221336.

Original languageEnglish
JournalEvidence-Based Mental Health
Volume23
Issue number1
Pages (from-to)2-7
Number of pages6
ISSN1362-0347
DOIs
Publication statusPublished - Feb 2020

ID: 59449216