Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial

Redas Trepiakas; Annika Berntsen; Sine Reker Hadrup; Jon Bjørn; Poul F Geertsen; Per Thor Straten; Mads H Andersen; Anders E Pedersen; Amir Soleimani; Torben Lorentzen; Julia S Johansen; Inge Marie Svane

doi:10.3109/14653241003774045

Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial

Redas Trepiakas, Annika Berntsen, Sine Reker Hadrup, Jon Bjørn, Poul F Geertsen, Per Thor Straten, Mads H Andersen, Anders E Pedersen, Amir Soleimani, Torben Lorentzen, Julia S Johansen, Inge Marie Svane

73 Citations (Scopus)

Abstract

Dendritic cells are regarded as the most effective antigen presenting cells and coordinators of the immune response and therefore suitable as vaccine basis. Here we present results from a clinical study in which patients with malignant melanoma (MM) with verified progressive disease received vaccination with autologous monocyte-derived mature dendritic cells (DC) pulsed with p53, survivin and telomerase-derived peptides (HLA-A2+ patients) or with autologous/allogeneic tumor lysate (HLA-A2(−) patients) in combination with low-dose interleukin (IL)-2 and interferon (IFN)-alpha2b.

Original language	English
Journal	Cytotherapy
Volume	12
Issue number	6
Pages (from-to)	721-34
Number of pages	14
ISSN	1465-3249
DOIs	https://doi.org/10.3109/14653241003774045
Publication status	Published - 1 Oct 2010

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Trepiakas, R., Berntsen, A., Hadrup, S. R., Bjørn, J., Geertsen, P. F., Straten, P. T., Andersen, M. H., Pedersen, A. E., Soleimani, A., Lorentzen, T., Johansen, J. S., & Svane, I. M. (2010). Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial. Cytotherapy, 12(6), 721-34. https://doi.org/10.3109/14653241003774045

Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial. / Trepiakas, Redas; Berntsen, Annika; Hadrup, Sine Reker et al.
In: Cytotherapy, Vol. 12, No. 6, 01.10.2010, p. 721-34.

Research output: Contribution to journal › Journal article › Research › peer-review

Trepiakas, R, Berntsen, A, Hadrup, SR, Bjørn, J, Geertsen, PF, Straten, PT , Andersen, MH, Pedersen, AE, Soleimani, A, Lorentzen, T , Johansen, JS & Svane, IM 2010, 'Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial', Cytotherapy, vol. 12, no. 6, pp. 721-34. https://doi.org/10.3109/14653241003774045

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AU - Bjørn, Jon

AU - Geertsen, Poul F

AU - Straten, Per Thor

AU - Andersen, Mads H

AU - Pedersen, Anders E

AU - Soleimani, Amir

AU - Lorentzen, Torben

AU - Johansen, Julia S

AU - Svane, Inge Marie

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Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial

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