Vaccination af personer, der modtager immunsuppressiv behandling

Zitta Barrella Harboe; Peter Henrik Andersen; Peter Asdahl; Trine Bertelsen; Stephan Bramow; Henrik Jørn Ditzel; Christina Ekenberg; Marie Helleberg; Jens Ulrik Jensen; Mette Julsgaard; Carsten Schade Larsen; Hans Henrik Lawaetz Schultz; Daria Podlekareva; Susanne Dam Nielsen; Karin Skov; Anne Troldborg; Søren Jensen-Fangel

doi:10.61409/V04250249

Vaccination af personer, der modtager immunsuppressiv behandling

Translated title of the contribution: Vaccination of individuals undergoing immunosuppressive therapy

Zitta Barrella Harboe^*, Peter Henrik Andersen, Peter Asdahl, Trine Bertelsen, Stephan Bramow, Henrik Jørn Ditzel, Christina Ekenberg, Marie Helleberg, Jens Ulrik Jensen, Mette Julsgaard, Carsten Schade Larsen, Hans Henrik Lawaetz Schultz, Daria Podlekareva, Susanne Dam Nielsen, Karin Skov, Anne Troldborg, Søren Jensen-Fangel

^*Corresponding author for this work

Abstract

Protecting individuals undergoing immunosuppressive therapy through vaccination remains a clinical challenge due to the heterogeneity of underlying conditions and immunosuppressive treatments. These patients are at increased risk of severe infections, yet vaccination uptake remains suboptimal. Although vaccine responses may be reduced, this review finds vaccination to be generally safe, except for live attenuated vaccines, which should be avoided due to the risk of severe disease. A structured, multidisciplinary approach to vaccination may enhance uptake and improve protection in this vulnerable patient group.

Translated title of the contribution	Vaccination of individuals undergoing immunosuppressive therapy
Original language	Danish
Article number	V04250249
Journal	Ugeskrift for Laeger
Volume	187
Issue number	46
Pages (from-to)	1-10
Number of pages	10
ISSN	0041-5782
DOIs	https://doi.org/10.61409/V04250249
Publication status	Published - 10 Nov 2025

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10.61409/V04250249Licence: CC BY-NC-ND

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Harboe, Z. B., Andersen, P. H., Asdahl, P., Bertelsen, T., Bramow, S., Ditzel, H. J., Ekenberg, C., Helleberg, M., Jensen, J. U., Julsgaard, M., Larsen, C. S., Schultz, H. H. L., Podlekareva, D., Nielsen, S. D., Skov, K., Troldborg, A., & Jensen-Fangel, S. (2025). Vaccination af personer, der modtager immunsuppressiv behandling. Ugeskrift for Laeger, 187(46), 1-10. Article V04250249. https://doi.org/10.61409/V04250249

Harboe, ZB, Andersen, PH, Asdahl, P, Bertelsen, T, Bramow, S, Ditzel, HJ, Ekenberg, C , Helleberg, M, Jensen, JU, Julsgaard, M, Larsen, CS, Schultz, HHL , Podlekareva, D , Nielsen, SD, Skov, K, Troldborg, A & Jensen-Fangel, S 2025, 'Vaccination af personer, der modtager immunsuppressiv behandling', Ugeskrift for Laeger, vol. 187, no. 46, V04250249, pp. 1-10. https://doi.org/10.61409/V04250249

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title = "Vaccination af personer, der modtager immunsuppressiv behandling",

abstract = "Protecting individuals undergoing immunosuppressive therapy through vaccination remains a clinical challenge due to the heterogeneity of underlying conditions and immunosuppressive treatments. These patients are at increased risk of severe infections, yet vaccination uptake remains suboptimal. Although vaccine responses may be reduced, this review finds vaccination to be generally safe, except for live attenuated vaccines, which should be avoided due to the risk of severe disease. A structured, multidisciplinary approach to vaccination may enhance uptake and improve protection in this vulnerable patient group.",

keywords = "Humans, Immunosuppressive Agents/adverse effects, Vaccination/adverse effects, Immunocompromised Host, Vaccines, Attenuated/adverse effects, Vaccines/administration \& dosage, Immunosuppression Therapy/adverse effects",

author = "Harboe, \{Zitta Barrella\} and Andersen, \{Peter Henrik\} and Peter Asdahl and Trine Bertelsen and Stephan Bramow and Ditzel, \{Henrik J{\o}rn\} and Christina Ekenberg and Marie Helleberg and Jensen, \{Jens Ulrik\} and Mette Julsgaard and Larsen, \{Carsten Schade\} and Schultz, \{Hans Henrik Lawaetz\} and Daria Podlekareva and Nielsen, \{Susanne Dam\} and Karin Skov and Anne Troldborg and S{\o}ren Jensen-Fangel",

note = "Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.",

year = "2025",

month = nov,

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doi = "10.61409/V04250249",

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T1 - Vaccination af personer, der modtager immunsuppressiv behandling

AU - Harboe, Zitta Barrella

AU - Andersen, Peter Henrik

AU - Asdahl, Peter

AU - Bertelsen, Trine

AU - Bramow, Stephan

AU - Ditzel, Henrik Jørn

AU - Ekenberg, Christina

AU - Helleberg, Marie

AU - Jensen, Jens Ulrik

AU - Julsgaard, Mette

AU - Larsen, Carsten Schade

AU - Schultz, Hans Henrik Lawaetz

AU - Podlekareva, Daria

AU - Nielsen, Susanne Dam

AU - Skov, Karin

AU - Troldborg, Anne

AU - Jensen-Fangel, Søren

N1 - Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

PY - 2025/11/10

Y1 - 2025/11/10

N2 - Protecting individuals undergoing immunosuppressive therapy through vaccination remains a clinical challenge due to the heterogeneity of underlying conditions and immunosuppressive treatments. These patients are at increased risk of severe infections, yet vaccination uptake remains suboptimal. Although vaccine responses may be reduced, this review finds vaccination to be generally safe, except for live attenuated vaccines, which should be avoided due to the risk of severe disease. A structured, multidisciplinary approach to vaccination may enhance uptake and improve protection in this vulnerable patient group.

AB - Protecting individuals undergoing immunosuppressive therapy through vaccination remains a clinical challenge due to the heterogeneity of underlying conditions and immunosuppressive treatments. These patients are at increased risk of severe infections, yet vaccination uptake remains suboptimal. Although vaccine responses may be reduced, this review finds vaccination to be generally safe, except for live attenuated vaccines, which should be avoided due to the risk of severe disease. A structured, multidisciplinary approach to vaccination may enhance uptake and improve protection in this vulnerable patient group.

KW - Humans

KW - Immunosuppressive Agents/adverse effects

KW - Vaccination/adverse effects

KW - Immunocompromised Host

KW - Vaccines, Attenuated/adverse effects

KW - Vaccines/administration & dosage

KW - Immunosuppression Therapy/adverse effects

UR - https://www.scopus.com/pages/publications/105022521905

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DO - 10.61409/V04250249

M3 - Review

C2 - 41268998

SN - 0041-5782

VL - 187

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EP - 10

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 46

M1 - V04250249

ER -

Vaccination af personer, der modtager immunsuppressiv behandling

Abstract

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