Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Utility of melatonin to treat surgical stress after major vascular surgery--a safety study.

Research output: Contribution to journalJournal articleResearchpeer-review

  1. The effect of melatonin on endothelial dysfunction in patients after acute coronary syndrome: The MEFACS randomized clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Melatonin: an ancient molecule that makes oxygen metabolically tolerable

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Genome-wide cell-free DNA fragmentation in patients with cancer

    Research output: Contribution to journalLetterResearchpeer-review

  2. Triage for selection to colonoscopy?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Clean Colorectum at Diagnostic Colonoscopy: Subsequent Detection of Extracolonic Malignancies by Plasma Protein Biomarkers?

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Bülent Kücükakin
  • Jens Lykkesfeldt
  • Hans Jørgen Nielsen
  • Russel J Reiter
  • Jacob Rosenberg
  • Ismail Gögenur
View graph of relations
Surgery for abdominal aortic aneurysm is associated with elevated oxidative stress. As an antioxidant in animal and human studies, melatonin has the potential of ameliorating some of this oxidative stress, but melatonin has never been administered to adults during surgery for the purpose of reducing oxidative damage. The aim of this pilot study was to evaluate the safety of various doses of melatonin administered during or after surgery and to monitor the changes in biomarkers of oxidative stress and inflammation during the pre-, intra-, and postoperative period. Six patients undergoing aortic surgery received 10 (n = 2), 30 (n = 2) or 60 (n = 2) mg melatonin intravenously in the intraoperative phase and 10 mg orally for three nights after surgery. Patients were monitored for hemodynamic parameters during and after surgery. Any unexpected events during the hospitalization were registered. Blood samples were collected preoperatively and at 5 min, 6 hr and 24 hr after clamp removal or after re-circulation of the first leg and the samples were analyzed for malondialdehyde (MDA), ascorbic acid (AA), dehydroascorbic acid (DHA), and interleukin-6 (IL-6). Troponin I (TpI) and C-reactive protein (CRP) were also measured for 4 days after surgery. Melatonin administration did not change hemodynamic parameters (mean arterial pressure or pulse rate) during surgery (P = 0.499 and 0.149, respectively), but oxidative stress parameters (MDA and AA) decreased significantly (P = 0.014 and 0.001, respectively). There was a significant increase in the inflammatory parameters (IL-6 and CRP) (P = 0.001 and 0.001, respectively) and an increase in TpI (P = 0.009) as a consequence of surgery. These were not influenced by melatonin treatment. Treatment of patients undergoing major aortic surgery with melatonin intravenously up to 60 mg in the intraoperative phase was safe and without complications. Melatonin may decrease oxidative damage resulting from surgery, but randomized clinical trials are required before definitive conclusions can be drawn regarding the clinical benefit of melatonin in surgical situations.
Original languageEnglish
JournalJournal of Pineal Research
Volume44
Issue number4
Pages (from-to)426-31
Number of pages5
ISSN0742-3098
DOIs
Publication statusPublished - 2008

    Research areas

  • Aged, Antioxidants, Aortic Aneurysm, Abdominal, Biological Markers, Female, Hemodynamics, Humans, Inflammation, Inflammation Mediators, Male, Melatonin, Middle Aged, Oxidative Stress, Pilot Projects, Time Factors, Vascular Surgical Procedures

ID: 32532675