Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Use-Dependent Plasticity in Human Primary Motor Hand Area: Synergistic Interplay Between Training and Immobilization

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Task-Modulated Cortical Representations of Natural Sound Source Categories

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Neocortical Development in Brain of Young Children-A Stereological Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Working Memory Modulation of Frontoparietal Network Connectivity in First-Episode Schizophrenia

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The Crossed Projection to the Striatum in Two Species of Monkey and in Humans: Behavioral and Evolutionary Significance

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. No trace of phase: Corticomotor excitability is not tuned by phase of pericentral mu-rhythm

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Altered orbitofrontal sulcogyral patterns in gambling disorder: a multicenter study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Training and immobilization are powerful drivers of use-dependent plasticity in human primary motor hand area (M1HAND). In young right-handed volunteers, corticomotor representations of the left first dorsal interosseus and abductor digiti minimi muscles were mapped with neuronavigated transcranial magnetic stimulation (TMS) to elucidate how finger-specific training and immobilization interact within M1HAND. A first group of volunteers trained to track a moving target on a smartphone with the left index or little finger for one week. Linear sulcus shape-informed TMS mapping revealed that the tracking skill acquired with the trained finger was transferred to the nontrained finger of the same hand. The cortical representations of the trained and nontrained finger muscle converged in proportion with skill transfer. In a second group, the index or little finger were immobilized for one week. Immobilization alone attenuated the corticomotor representation and pre-existing tracking skill of the immobilized finger. In a third group, the detrimental effects of finger immobilization were blocked by concurrent training of the nonimmobilized finger. Conversely, immobilization of the nontrained fingers accelerated learning in the adjacent trained finger during the first 2 days of training. Together, the results provide novel insight into use-dependent cortical plasticity, revealing synergistic rather than competitive interaction patterns within M1HAND.

Original languageEnglish
JournalCerebral Cortex
Volume29
Issue number1
Pages (from-to)356
Number of pages371
ISSN1047-3211
DOIs
Publication statusPublished - 1 Jan 2019

ID: 55528404