Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Use of hydroxychloroquine and risk of major adverse cardiovascular events in patients with lupus erythematosus: A Danish nationwide cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prevalence of psoriasis among adults in the US 2009-2010 and 2013-2014 National Health and Nutrition Examination Surveys

    Research output: Contribution to journalLetterResearchpeer-review

  2. Symptom burden of atopic dermatitis in early childhood assessed from daily monitoring of symptoms and topical steroid use

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  4. Risk of systemic infections in adults with atopic dermatitis: A nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Limited data suggest that hydroxychloroquine may affect risk of cardiovascular disease in patients with lupus erythematosus (LE).

OBJECTIVE: To investigate whether hydroxychloroquine treatment is associated with major adverse cardiovascular events (MACE) (myocardial infarction, ischemic stroke, or cardiovascular-associated death) in patients with cutaneous LE (CLE) or systemic LE (SLE).

METHODS: Based on the Danish nationwide registers, an observational cohort study was conducted including patients with first-time diagnosis of CLE or SLE (between 1997 and 2017). Cox regression models calculating the hazard ratio (HR) analyzing the risk of MACE were performed comparing time on and off hydroxychloroquine (including never users). The models were adjusted for age, sex, socioeconomic status, concomitant treatment, and cardiovascular risk factors.

RESULTS: Among 4587 patients with LE, 51% (n = 2343) were treated with hydroxychloroquine during the study period. An inverse association between use of hydroxychloroquine and MACE risk was observed among patients with SLE (adjusted HR, 0.65; 95% confidence interval, 0.46-0.90) and patients with CLE (adjusted HR, 0.71; 95% confidence interval, 0.42-1.19). Consistent results were found in sensitivity analyses including a case-time control design.

LIMITATIONS: No information on disease activity/severity was available.

CONCLUSION: Our findings indicate an opportunity to reduce the risk of cardiovascular events in patients with LE through use of hydroxychloroquine.

Original languageEnglish
JournalJournal of the American Academy of Dermatology
Issue number4
Pages (from-to)930-937
Number of pages8
Publication statusPublished - Apr 2021

    Research areas

  • Adult, Brain Ischemia/chemically induced, Cardiovascular Diseases/mortality, Cohort Studies, Comorbidity, Confounding Factors, Epidemiologic, Denmark/epidemiology, Diabetes Mellitus/epidemiology, Female, Humans, Hydroxychloroquine/adverse effects, Hypercholesterolemia/epidemiology, Hypertension/epidemiology, Incidence, Income, Lupus Erythematosus, Cutaneous/drug therapy, Lupus Erythematosus, Systemic/drug therapy, Male, Middle Aged, Myocardial Infarction/chemically induced, Proportional Hazards Models, Registries, Risk, Smoking Cessation/statistics & numerical data, Smoking/epidemiology, Social Class, major adverse cardiovascular event, systemic lupus erythematosus, hydroxychloroquine, cutaneous lupus erythematosus, cardiovascular disease

ID: 67625557