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The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Use of contemporary protease inhibitors and risk of incident chronic kidney disease in HIV-positive persons; the D:A:D Study

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  • D:A:D study group
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BACKGROUND: It is unclear if use of contemporary protease inhibitors (PIs) pose a similar chronic kidney disease (CKD) risk as older PIs.

METHODS: D:A:D participants were followed to CKD, last visit or 2016. Adjusted Poisson regression assessed associations between CKD and boosted atazanavir (ATV/r) and darunavir (DRV/r).

RESULTS: CKD incidence (10.0/1000 PYFU [95%CI 9.5-10.4]) increased gradually with increasing exposure to ATV/r, but less clearly for DRV/r. After adjustment, only exposure to ATV/r (1.4 [1.2-1.6]), but not DRV/r (1.0 [0.8-1.3]) remained significantly associated with CKD.

CONCLUSION: While DRV/r use was not significantly associated with CKD an increasing incidence with longer ATV/r use was confirmed.

Original languageEnglish
JournalThe Journal of infectious diseases
ISSN0022-1899
DOIs
Publication statusE-pub ahead of print - 16 Jul 2019

ID: 57969877