Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium

Suzanne C Dixon; Christina M Nagle; Nicolas Wentzensen; Britton Trabert; Alicia Beeghly-Fadiel; Joellen M Schildkraut; Kirsten B Moysich; Anna deFazio; Harvey A Risch; Mary Anne Rossing; Jennifer A Doherty; Kristine G Wicklund; Marc T Goodman; Francesmary Modugno; Roberta B Ness; Robert P Edwards; Allan Jensen; Susanne K Kjær; Estrid Høgdall; Andrew Berchuck; Daniel W Cramer; Kathryn L Terry; Elizabeth M Poole; Elisa V Bandera; Lisa E Paddock; Hoda Anton-Culver; Argyrios Ziogas; Usha Menon; Simon A Gayther; Susan J Ramus; Aleksandra Gentry-Maharaj; Celeste Leigh Pearce; Anna H Wu; Malcolm C Pike; Penelope M Webb; Australian Ovarian Cancer Study Group

doi:10.1038/bjc.2017.68

Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium

Suzanne C Dixon, Christina M Nagle, Nicolas Wentzensen, Britton Trabert, Alicia Beeghly-Fadiel, Joellen M Schildkraut, Kirsten B Moysich, Anna deFazio, Harvey A Risch, Mary Anne Rossing, Jennifer A Doherty, Kristine G Wicklund, Marc T Goodman, Francesmary Modugno, Roberta B Ness, Robert P Edwards, Allan Jensen, Susanne K Kjær, Estrid Høgdall, Andrew BerchuckDaniel W Cramer, Kathryn L Terry, Elizabeth M Poole, Elisa V Bandera, Lisa E Paddock, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon A Gayther, Susan J Ramus, Aleksandra Gentry-Maharaj, Celeste Leigh Pearce, Anna H Wu, Malcolm C Pike, Penelope M Webb, Australian Ovarian Cancer Study Group

Department of Pathology

19 Citations (Scopus)

Abstract

BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited.

METHODS: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths).

RESULTS: Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95% confidence intervals): aspirin 0.96 (0.88-1.04); non-aspirin NSAIDs 0.97 (0.89-1.05); acetaminophen 1.01 (0.93-1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR=0.89 (0.82-0.98)).

CONCLUSIONS: Although this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted.

Original language	English
Journal	B J C
Volume	116
Issue number	9
Pages (from-to)	1223-1228
Number of pages	6
ISSN	0007-0920
DOIs	https://doi.org/10.1038/bjc.2017.68
Publication status	Published - 25 Apr 2017

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Dixon, S. C., Nagle, C. M., Wentzensen, N., Trabert, B., Beeghly-Fadiel, A., Schildkraut, J. M., Moysich, K. B., deFazio, A., Risch, H. A., Rossing, M. A., Doherty, J. A., Wicklund, K. G., Goodman, M. T., Modugno, F., Ness, R. B., Edwards, R. P., Jensen, A., Kjær, S. K., Høgdall, E., ... Australian Ovarian Cancer Study Group (2017). Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium. B J C, 116(9), 1223-1228. https://doi.org/10.1038/bjc.2017.68

Dixon, SC, Nagle, CM, Wentzensen, N, Trabert, B, Beeghly-Fadiel, A, Schildkraut, JM, Moysich, KB, deFazio, A, Risch, HA, Rossing, MA, Doherty, JA, Wicklund, KG, Goodman, MT, Modugno, F, Ness, RB, Edwards, RP, Jensen, A, Kjær, SK , Høgdall, E, Berchuck, A, Cramer, DW, Terry, KL, Poole, EM, Bandera, EV, Paddock, LE, Anton-Culver, H, Ziogas, A, Menon, U, Gayther, SA, Ramus, SJ, Gentry-Maharaj, A, Pearce, CL, Wu, AH, Pike, MC, Webb, PM & Australian Ovarian Cancer Study Group 2017, 'Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium', B J C, vol. 116, no. 9, pp. 1223-1228. https://doi.org/10.1038/bjc.2017.68

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abstract = "BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited.METHODS: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths).RESULTS: Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95\% confidence intervals): aspirin 0.96 (0.88-1.04); non-aspirin NSAIDs 0.97 (0.89-1.05); acetaminophen 1.01 (0.93-1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR=0.89 (0.82-0.98)).CONCLUSIONS: Although this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted.",

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author = "Dixon, \{Suzanne C\} and Nagle, \{Christina M\} and Nicolas Wentzensen and Britton Trabert and Alicia Beeghly-Fadiel and Schildkraut, \{Joellen M\} and Moysich, \{Kirsten B\} and Anna deFazio and Risch, \{Harvey A\} and Rossing, \{Mary Anne\} and Doherty, \{Jennifer A\} and Wicklund, \{Kristine G\} and Goodman, \{Marc T\} and Francesmary Modugno and Ness, \{Roberta B\} and Edwards, \{Robert P\} and Allan Jensen and Kj{\ae}r, \{Susanne K\} and Estrid H{\o}gdall and Andrew Berchuck and Cramer, \{Daniel W\} and Terry, \{Kathryn L\} and Poole, \{Elizabeth M\} and Bandera, \{Elisa V\} and Paddock, \{Lisa E\} and Hoda Anton-Culver and Argyrios Ziogas and Usha Menon and Gayther, \{Simon A\} and Ramus, \{Susan J\} and Aleksandra Gentry-Maharaj and Pearce, \{Celeste Leigh\} and Wu, \{Anna H\} and Pike, \{Malcolm C\} and Webb, \{Penelope M\} and \{Australian Ovarian Cancer Study Group\}",

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doi = "10.1038/bjc.2017.68",

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TY - JOUR

T1 - Use of common analgesic medications and ovarian cancer survival

T2 - results from a pooled analysis in the Ovarian Cancer Association Consortium

AU - Dixon, Suzanne C

AU - Nagle, Christina M

AU - Wentzensen, Nicolas

AU - Trabert, Britton

AU - Beeghly-Fadiel, Alicia

AU - Schildkraut, Joellen M

AU - Moysich, Kirsten B

AU - deFazio, Anna

AU - Risch, Harvey A

AU - Rossing, Mary Anne

AU - Doherty, Jennifer A

AU - Wicklund, Kristine G

AU - Goodman, Marc T

AU - Modugno, Francesmary

AU - Ness, Roberta B

AU - Edwards, Robert P

AU - Jensen, Allan

AU - Kjær, Susanne K

AU - Høgdall, Estrid

AU - Berchuck, Andrew

AU - Cramer, Daniel W

AU - Terry, Kathryn L

AU - Poole, Elizabeth M

AU - Bandera, Elisa V

AU - Paddock, Lisa E

AU - Anton-Culver, Hoda

AU - Ziogas, Argyrios

AU - Menon, Usha

AU - Gayther, Simon A

AU - Ramus, Susan J

AU - Gentry-Maharaj, Aleksandra

AU - Pearce, Celeste Leigh

AU - Wu, Anna H

AU - Pike, Malcolm C

AU - Webb, Penelope M

AU - Australian Ovarian Cancer Study Group

PY - 2017/4/25

Y1 - 2017/4/25

N2 - BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited.METHODS: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths).RESULTS: Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95% confidence intervals): aspirin 0.96 (0.88-1.04); non-aspirin NSAIDs 0.97 (0.89-1.05); acetaminophen 1.01 (0.93-1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR=0.89 (0.82-0.98)).CONCLUSIONS: Although this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted.

AB - BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited.METHODS: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths).RESULTS: Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95% confidence intervals): aspirin 0.96 (0.88-1.04); non-aspirin NSAIDs 0.97 (0.89-1.05); acetaminophen 1.01 (0.93-1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR=0.89 (0.82-0.98)).CONCLUSIONS: Although this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted.

KW - Journal Article

UR - https://www.scopus.com/pages/publications/85016433040

U2 - 10.1038/bjc.2017.68

DO - 10.1038/bjc.2017.68

M3 - Journal article

C2 - 28350790

SN - 0007-0920

VL - 116

SP - 1223

EP - 1228

JO - B J C

JF - B J C

IS - 9

ER -

Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium

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