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The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Use and success of In Vitro Fertilization following Restorative Proctocolectomy and Ileal Pouch-Anal Anastomosis. A nationwide 17-year cohort study

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BACKGROUND AND AIMS: Fertility decreases in women following restorative proctocolectomy for ulcerative colitis. The use and success of in vitro fertilization after restorative proctocolectomy for ulcerative colitis is not systematically studied.We aimed to estimate the use and success of in vitro fertilization treatment in female ulcerative colitis patients, with and without restorative proctocolectomy.

METHODS: Women of fertile age (15-49 years) with restorative proctocolectomy for ulcerative colitis were compared with females with ulcerative colitis without restorative proctocolectomy. Data from the IVF registry from 1994-2010 was crosslinked with data from the National Danish Patient Registry and the Medical Birth Registry.

RESULTS: In vitro fertilization is significantly more frequent in females with restorative proctocolectomy compared with females without restorative proctocolectomy, adjusted Hazard Ratio 3.2, 95% CI [2.5;4.0]. The odds for having a live birth after in vitro fertilization is no different in females with restorative proctocolectomy compared with females without restorative proctocolectomy, adjusted Odds Ratio 0.8, 95% CI [0.6;1.1].The percentage of children born as a result of in vitro fertilization is significantly higher in females with restorative proctocolectomy compared with females without restorative proctocolectomy (31.0%, 95% CI [24.1; 37.7]) vs. 5.0%, 95% CI [4.4; 5.6]).

CONCLUSION: Females with restorative proctocolectomy for ulcerative colitis have increased incidence of in vitro fertilization by more than a factor 3, the odds that a treatment results in a live birth is similar and 6 times more children are born as a result of in vitro fertilization compared with females without restorative proctocolectomy.

Original languageEnglish
JournalJournal of Crohn's & colitis
ISSN1873-9946
DOIs
Publication statusE-pub ahead of print - 6 Mar 2019

ID: 56782594