Abstract
AIM: Assays for cerebrospinal fluid (CSF) levels of total tau, phospho-tau protein and beta-amyloid 1-42 have been available for some years. The aim of the study was to assess the usability of these biomarkers in a mixed population of tertiary dementia referral patients in a university-based memory clinic.
METHODS: 147 consecutive patients with a lumbar puncture as a part of their clinical workup were studied. A retrospective diagnosis was established based on consensus criteria without the knowledge of the CSF results.
RESULTS: When diagnosing Alzheimer's disease (AD) compared to other diagnoses, the sensitivity of a single abnormal value was between 33 and 66%. The specificity was high except when discriminating AD from amnestic mild cognitive impairment. Two or more abnormal markers further increased the specificity and decreased the sensitivity.
CONCLUSION: In a tertiary setting, abnormal CSF biomarker results may be of a diagnostic value - whereas normal results do not exclude neurodegenerative disease.
| Original language | English |
|---|---|
| Journal | Dementia and Geriatric Cognitive Disorders |
| Volume | 25 |
| Issue number | 6 |
| Pages (from-to) | 553-8 |
| Number of pages | 6 |
| ISSN | 1420-8008 |
| DOIs | |
| Publication status | Published - 2008 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Alzheimer Disease/cerebrospinal fluid
- Amyloid beta-Peptides/cerebrospinal fluid
- Biomarkers/cerebrospinal fluid
- Female
- Humans
- Male
- Memory Disorders/cerebrospinal fluid
- Middle Aged
- Outpatient Clinics, Hospital
- Peptide Fragments/cerebrospinal fluid
- Referral and Consultation
- Retrospective Studies
- Sensitivity and Specificity
- tau Proteins/cerebrospinal fluid
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