Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Progressive DNA and RNA damage from oxidation after aneurysmal subarachnoid haemorrhage in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Urinary markers of nucleic acid oxidation in Danish overweight/obese children and youths

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Assays for urinary biomarkers of oxidatively damaged nucleic acids

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Body iron is a contributor to oxidative damage of DNA

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Haploinsufficiency of ARHGAP42 is associated with hypertension

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Heart failure and the prognostic impact and incidence of new-onset of diabetes mellitus: a nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The impact of implantable cardioverter-defibrillator implantation on health-related quality of life in the DANISH trial

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The relationship between RNA and DNA oxidation and pharmacological treatment has not been systematically investigated in patients with type 2 diabetes (T2D). We aimed to investigate the association between pharmacological treatments and levels of urinary markers of nucleic acid oxidation in T2D patients. Vejle Diabetes Biobank cohort data was nested into nationwide registry data. Multiple logistic regression was used to associate drug usage with risk of high (above median) RNA and DNA oxidation. Data from 2664 T2D patients (64% male, age range: 25-75) were included. Questionnaire-validated lipid lowering drug use was associated with low RNA oxidation (Odds ratio, OR 0.71, 95% CI: [0.59-0.87]). Insulin and non-specific antidiabetic drugs were associated with low DNA oxidation (insulin: OR 0.60, 95% CI [0.49-0.73]). Oral antidiabetics were associated with high DNA oxidation and RNA oxidation (OR 1.30, 95% CI [1.10-1.53] and OR 1.26, 95% CI [1.07-1.29]). Our findings indicate that diabetes-related drugs are associated with RNA and DNA oxidation and further studies are required to determine causality in T2D patients.

Original languageEnglish
JournalFree Radical Research
Pages (from-to)1-10
Number of pages10
ISSN1071-5762
DOIs
Publication statusE-pub ahead of print - 4 Jun 2019

ID: 57340695