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Urinary growth hormone excretion in acromegaly: diagnostic value in mild disease activity

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@article{0be3a44901714d29a92037572dff9aeb,
title = "Urinary growth hormone excretion in acromegaly: diagnostic value in mild disease activity",
abstract = "The biochemical assessment of disease activity in acromegaly still presents a problem, especially in treated patients with mild clinical symptoms. We therefore examined the diagnostic value of the measurement of urinary growth hormone (GH) excretion in seventy unselected patients with acromegaly of different activity by comparing it to serum GH, serum insulin-like growth factor I (IGF-I) and clinical activity. There were highly significant, positive correlations between urinary GH and serum GH, serum IGF-I as well as clinical activity score (p < 0.00005), although some overlap between the groups was observed. In seven patients with low serum GH values (< 2.0 micrograms/l) discordant results were found. Two of the seven patients were clinically mildly active, but only IGF-I was either elevated or within the upper normal range; in three other patients who appeared clinically cured either IGF-I (N = 1) or urinary GH (n = 2) alone were increased. In the remaining two patients elevated serum IGF-I and urinary GH as well as activity score suggested disease activity. Thus, in the majority of cases, urinary GH was significantly correlated to the other three parameters, but added little information to that obtained by serum IGF-I. In conclusion, urinary GH measurements in difficult cases may provide a more direct information on the GH status than IGF-I.",
keywords = "Acromegaly, Adult, Aged, Enzyme-Linked Immunosorbent Assay, Female, Growth Hormone, Humans, Insulin-Like Growth Factor I, Male, Middle Aged, Pituitary Neoplasms, Regression Analysis",
author = "Main, {K M} and J Lindholm and M Vandeweghe and Skakkebaek, {N E}",
year = "1993",
month = "11",
language = "English",
volume = "129",
pages = "409--13",
journal = "Acta Endocrinologica",
issn = "0001-5598",
publisher = "Periodica",
number = "5",

}

RIS

TY - JOUR

T1 - Urinary growth hormone excretion in acromegaly

T2 - diagnostic value in mild disease activity

AU - Main, K M

AU - Lindholm, J

AU - Vandeweghe, M

AU - Skakkebaek, N E

PY - 1993/11

Y1 - 1993/11

N2 - The biochemical assessment of disease activity in acromegaly still presents a problem, especially in treated patients with mild clinical symptoms. We therefore examined the diagnostic value of the measurement of urinary growth hormone (GH) excretion in seventy unselected patients with acromegaly of different activity by comparing it to serum GH, serum insulin-like growth factor I (IGF-I) and clinical activity. There were highly significant, positive correlations between urinary GH and serum GH, serum IGF-I as well as clinical activity score (p < 0.00005), although some overlap between the groups was observed. In seven patients with low serum GH values (< 2.0 micrograms/l) discordant results were found. Two of the seven patients were clinically mildly active, but only IGF-I was either elevated or within the upper normal range; in three other patients who appeared clinically cured either IGF-I (N = 1) or urinary GH (n = 2) alone were increased. In the remaining two patients elevated serum IGF-I and urinary GH as well as activity score suggested disease activity. Thus, in the majority of cases, urinary GH was significantly correlated to the other three parameters, but added little information to that obtained by serum IGF-I. In conclusion, urinary GH measurements in difficult cases may provide a more direct information on the GH status than IGF-I.

AB - The biochemical assessment of disease activity in acromegaly still presents a problem, especially in treated patients with mild clinical symptoms. We therefore examined the diagnostic value of the measurement of urinary growth hormone (GH) excretion in seventy unselected patients with acromegaly of different activity by comparing it to serum GH, serum insulin-like growth factor I (IGF-I) and clinical activity. There were highly significant, positive correlations between urinary GH and serum GH, serum IGF-I as well as clinical activity score (p < 0.00005), although some overlap between the groups was observed. In seven patients with low serum GH values (< 2.0 micrograms/l) discordant results were found. Two of the seven patients were clinically mildly active, but only IGF-I was either elevated or within the upper normal range; in three other patients who appeared clinically cured either IGF-I (N = 1) or urinary GH (n = 2) alone were increased. In the remaining two patients elevated serum IGF-I and urinary GH as well as activity score suggested disease activity. Thus, in the majority of cases, urinary GH was significantly correlated to the other three parameters, but added little information to that obtained by serum IGF-I. In conclusion, urinary GH measurements in difficult cases may provide a more direct information on the GH status than IGF-I.

KW - Acromegaly

KW - Adult

KW - Aged

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Growth Hormone

KW - Humans

KW - Insulin-Like Growth Factor I

KW - Male

KW - Middle Aged

KW - Pituitary Neoplasms

KW - Regression Analysis

M3 - Journal article

VL - 129

SP - 409

EP - 413

JO - Acta Endocrinologica

JF - Acta Endocrinologica

SN - 0001-5598

IS - 5

ER -

ID: 44978352