Urinary excretion of epsilondA is not predictive of cancer development: a prospective nested case-control study

Peter R Hillestrøm; Kristiina Nyssönen; Tomi-Pekka Tuomainen; Eero Pukkala; Jukka T Salonen; Henrik E Poulsen

doi:10.1080/10715760400022103

Urinary excretion of epsilondA is not predictive of cancer development: a prospective nested case-control study

Peter R Hillestrøm, Kristiina Nyssönen, Tomi-Pekka Tuomainen, Eero Pukkala, Jukka T Salonen, Henrik E Poulsen

Clinical Pharmacology, Department of

3 Citations (Scopus)

Abstract

Human biomonitoring of the lipid peroxidation DNA modification 1,N6-ethenodeoxyadenosine (epsilondA) excreted into urine is thought to be a potential marker for oxidative stress-related DNA damage and human cancer. We have tested this hypothesis in a prospective, nested case-control study. During the years 1984-1989, 24-h urines were collected from 1956 men in the Kuopio Ischaemic Heart Disease (KIHD) Risk Factor Study. epsilondA concentrations were measured by LC-MS/MS in 24-h urine samples from 47 men with cancer diagnosed at follow up until 2001 and from 31 cancer free smoking-matched control subjects. Odds ratio for having higher than control median epsilon dA excretion rate and cancer, estimated by binary logistic regression, was 0.73 (95% CI 0.29-1.80, p = 0.49). In this study, the urinary excretion of epsilondA provides no additional prediction of cancer development in males after controlling for smoking.

Original language	English
Journal	Free Radical Research
Volume	39
Issue number	1
Pages (from-to)	51-3
Number of pages	3
ISSN	1071-5762
DOIs	https://doi.org/10.1080/10715760400022103
Publication status	Published - Jan 2005

Keywords

Adult
Body Mass Index
Body Weight
Case-Control Studies
Chromatography, Liquid
DNA/metabolism
DNA Adducts
DNA Damage
Deoxyadenosines/urine
Humans
Lipid Peroxidation
Logistic Models
Male
Mass Spectrometry
Middle Aged
Neoplasms/diagnosis
Odds Ratio
Oxidative Stress
Prospective Studies
Risk
Risk Factors
Smoking
Time Factors

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10.1080/10715760400022103

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title = "Urinary excretion of epsilondA is not predictive of cancer development: a prospective nested case-control study",

abstract = "Human biomonitoring of the lipid peroxidation DNA modification 1,N6-ethenodeoxyadenosine (epsilondA) excreted into urine is thought to be a potential marker for oxidative stress-related DNA damage and human cancer. We have tested this hypothesis in a prospective, nested case-control study. During the years 1984-1989, 24-h urines were collected from 1956 men in the Kuopio Ischaemic Heart Disease (KIHD) Risk Factor Study. epsilondA concentrations were measured by LC-MS/MS in 24-h urine samples from 47 men with cancer diagnosed at follow up until 2001 and from 31 cancer free smoking-matched control subjects. Odds ratio for having higher than control median epsilon dA excretion rate and cancer, estimated by binary logistic regression, was 0.73 (95% CI 0.29-1.80, p = 0.49). In this study, the urinary excretion of epsilondA provides no additional prediction of cancer development in males after controlling for smoking.",

keywords = "Adult, Body Mass Index, Body Weight, Case-Control Studies, Chromatography, Liquid, DNA/metabolism, DNA Adducts, DNA Damage, Deoxyadenosines/urine, Humans, Lipid Peroxidation, Logistic Models, Male, Mass Spectrometry, Middle Aged, Neoplasms/diagnosis, Odds Ratio, Oxidative Stress, Prospective Studies, Risk, Risk Factors, Smoking, Time Factors",

author = "Hillestr{\o}m, {Peter R} and Kristiina Nyss{\"o}nen and Tomi-Pekka Tuomainen and Eero Pukkala and Salonen, {Jukka T} and Poulsen, {Henrik E}",

year = "2005",

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language = "English",

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pages = "51--3",

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T1 - Urinary excretion of epsilondA is not predictive of cancer development

T2 - a prospective nested case-control study

AU - Hillestrøm, Peter R

AU - Nyssönen, Kristiina

AU - Tuomainen, Tomi-Pekka

AU - Pukkala, Eero

AU - Salonen, Jukka T

AU - Poulsen, Henrik E

PY - 2005/1

Y1 - 2005/1

N2 - Human biomonitoring of the lipid peroxidation DNA modification 1,N6-ethenodeoxyadenosine (epsilondA) excreted into urine is thought to be a potential marker for oxidative stress-related DNA damage and human cancer. We have tested this hypothesis in a prospective, nested case-control study. During the years 1984-1989, 24-h urines were collected from 1956 men in the Kuopio Ischaemic Heart Disease (KIHD) Risk Factor Study. epsilondA concentrations were measured by LC-MS/MS in 24-h urine samples from 47 men with cancer diagnosed at follow up until 2001 and from 31 cancer free smoking-matched control subjects. Odds ratio for having higher than control median epsilon dA excretion rate and cancer, estimated by binary logistic regression, was 0.73 (95% CI 0.29-1.80, p = 0.49). In this study, the urinary excretion of epsilondA provides no additional prediction of cancer development in males after controlling for smoking.

AB - Human biomonitoring of the lipid peroxidation DNA modification 1,N6-ethenodeoxyadenosine (epsilondA) excreted into urine is thought to be a potential marker for oxidative stress-related DNA damage and human cancer. We have tested this hypothesis in a prospective, nested case-control study. During the years 1984-1989, 24-h urines were collected from 1956 men in the Kuopio Ischaemic Heart Disease (KIHD) Risk Factor Study. epsilondA concentrations were measured by LC-MS/MS in 24-h urine samples from 47 men with cancer diagnosed at follow up until 2001 and from 31 cancer free smoking-matched control subjects. Odds ratio for having higher than control median epsilon dA excretion rate and cancer, estimated by binary logistic regression, was 0.73 (95% CI 0.29-1.80, p = 0.49). In this study, the urinary excretion of epsilondA provides no additional prediction of cancer development in males after controlling for smoking.

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KW - DNA Damage

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KW - Humans

KW - Lipid Peroxidation

KW - Logistic Models

KW - Male

KW - Mass Spectrometry

KW - Middle Aged

KW - Neoplasms/diagnosis

KW - Odds Ratio

KW - Oxidative Stress

KW - Prospective Studies

KW - Risk

KW - Risk Factors

KW - Smoking

KW - Time Factors

U2 - 10.1080/10715760400022103

DO - 10.1080/10715760400022103

M3 - Journal article

C2 - 15875811

SN - 1071-5762

VL - 39

SP - 51

EP - 53

JO - Free Radical Research

JF - Free Radical Research

IS - 1

ER -

Urinary excretion of epsilondA is not predictive of cancer development: a prospective nested case-control study

Abstract

Keywords

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