TY - JOUR
T1 - Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men
AU - Benson, Thea Emily
AU - Gaml-Sørensen, Anne
AU - Ernst, Andreas
AU - Brix, Nis
AU - Hougaard, Karin Sørig
AU - Hærvig, Katia Keglberg
AU - Ellekilde Bonde, Jens Peter
AU - Tøttenborg, Sandra Søgaard
AU - Lindh, Christian H
AU - Ramlau-Hansen, Cecilia Høst
AU - Toft, Gunnar
PY - 2021/2/11
Y1 - 2021/2/11
N2 - Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross-sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18-20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile-divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre-pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.
AB - Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross-sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18-20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile-divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre-pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.
KW - Bisphenol
KW - Endocrine disruptor
KW - Epidemiology
KW - Male fertility
KW - Semen quality
UR - http://www.scopus.com/inward/record.url?scp=85100696649&partnerID=8YFLogxK
U2 - 10.3390/ijerph18041742
DO - 10.3390/ijerph18041742
M3 - Journal article
C2 - 33670148
SN - 1661-7827
VL - 18
SP - 1
EP - 12
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 4
M1 - 1742
ER -