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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Upper Extremity DVT versus Lower Extremity DVT: Perspectives from the GARFIELD-VTE Registry

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  1. Effect of Anabolic-Androgenic Steroid Abuse on the Contact Activation System

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  2. Isolated Distal Deep Vein Thrombosis: Perspectives from the GARFIELD-VTE Registry

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  3. Characteristics and Management of Patients with Venous Thromboembolism: The GARFIELD-VTE Registry

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  2. Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE

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  3. Comparative effectiveness of oral anticoagulants in venous thromboembolism: GARFIELD-VTE

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  4. Anticoagulation therapy patterns for acute treatment of venous thromboembolism in GARFIELD-VTE patients

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  5. Isolated Distal Deep Vein Thrombosis: Perspectives from the GARFIELD-VTE Registry

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  • Walter Ageno
  • Sylvia Haas
  • Jeffrey I Weitz
  • Samuel Z Goldhaber
  • Alexander G G Turpie
  • Shinya Goto
  • Pantep Angchaisuksiri
  • Joern Dalsgaard Nielsen
  • Gloria Kayani
  • Alfredo E Farjat
  • Audrey Zaghdoun
  • Sebastian Schellong
  • Henri Bounameaux
  • Lorenzo G Mantovani
  • Paolo Prandoni
  • Harald Darius
  • Ajay K Kakkar
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Upper extremity deep vein thrombosis (UEDVT) is less common than lower extremity DVT (LEDVT) and consequently less well characterized. This study compared clinical characteristics and 1-year outcomes between 438 UEDVT patients and 7,602 LEDVT patients recruited in the GARFIELD-VTE registry. UEDVT patients were significantly more likely to have a central venous catheter than those with LEDVT (11.5% vs. 0.5%; p < 0.0001), and had a higher rate of active cancer (16.2%) or recent hospitalization (19.4%) compared with LEDVT patients (8.7% and 11.2%, respectively). Nearly all patients with UEDVT and LEDVT were initiated on anticoagulant therapy, which was a direct oral anticoagulant in one-third individuals in both groups. At 3, 6, and 12 months, the proportion of UEDVT and LEDVT patients who were receiving anticoagulant therapy was 82.6 and 87.4%, 66.0 and 72.6%, and 45.7 and 54.6%, respectively. In the UEDVT and LEDVT groups, VTE recurrence rate was 4.0 (95% confidence interval [CI], 2.4-6.7) and 5.5 (95% CI, 4.9-6.1) per 100 person-years, respectively; major bleed was noted in 1.3 (95% CI, 0.6-3.2) and 1.6 (95% CI, 1.3-1.9) per 100 person-years and all-cause mortality in 9.7 (95% CI, 7.1-13.4) and 6.7 (95% CI, 6.1-7.3) per 100 person-years, respectively. Hence, risk of recurrence was similar in the two groups whereas all-cause mortality was significantly higher in the UEDVT group than the LEDVT group (p = 0.0338). This latter finding was likely due to the high prevalence of cancer in the UEDVT group.

Original languageEnglish
JournalThrombosis and Haemostasis
Volume119
Issue number8
Pages (from-to)1365-1372
Number of pages8
ISSN0340-6245
DOIs
Publication statusPublished - Aug 2019

    Research areas

  • Administration, Oral, Adolescent, Adult, Aged, Aged, 80 and over, Anticoagulants/administration & dosage, Catheterization, Central Venous, Female, Hospitalization, Humans, Lower Extremity/physiopathology, Male, Middle Aged, Prevalence, Prospective Studies, Recurrence, Registries, Upper Extremity/physiopathology, Venous Thrombosis/complications, Young Adult

ID: 61882669