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The Capital Region of Denmark - a part of Copenhagen University Hospital
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UPF2 is a critical regulator of liver development, function and regeneration

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  1. Incidence, prevalence and risk factors for hepatitis C in Danish prisons

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  2. Disentangling the complexity of mobility of older medical patients in routine practice: An ethnographic study in Denmark

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Nonsense-mediated mRNA decay (NMD) is a post-transcriptional RNA surveillance process that facilitates the recognition and destruction of mRNAs bearing premature terminations codons (PTCs). Such PTC-containing (PTC+) mRNAs may arise from different processes, including erroneous processing and expression of pseudogenes, but also from more regulated events such as alternative splicing coupled NMD (AS-NMD). Thus, the NMD pathway serves both as a silencer of genomic noise and a regulator of gene expression. Given the early embryonic lethality in NMD deficient mice, uncovering the full regulatory potential of the NMD pathway in mammals will require the functional assessment of NMD in different tissues.
Original languageEnglish
JournalP L o S One
Volume5
Issue number7
Pages (from-to)e11650
ISSN1932-6203
DOIs
Publication statusPublished - 1 Jan 2010

ID: 32222792