Update on Sudden Unexpected Death in Epilepsy

Marius Kløvgaard; Anne Sabers; Philippe Ryvlin

doi:10.1016/j.ncl.2022.06.001

Update on Sudden Unexpected Death in Epilepsy

Marius Kløvgaard^*, Anne Sabers, Philippe Ryvlin

^*Corresponding author for this work

Abstract

Persons with epilepsy (PWE) have an up to 34-fold increased risk of dying suddenly and unexpectedly compared with the general population. Despite being potentially preventable by optimal care, sudden unexpected death in epilepsy (SUDEP) is one of the most frequent causes of death in PWE, especially in children and younger adults. The incidence of SUDEP in the general epilepsy population is rather consistent at 1.2 to 1.3 per 1000 person-year across series. Several risk factors for SUDEP have been identified, but with focal-to-bilateral or generalized tonic-clonic seizures and sleeping alone as the most significant. Thereby, optimal care and nocturnal surveillance might decrease the risk of SUDEP. Finally, PWE wants information about SUDEP, and providing this information might increase adherence to the treatment and thereby good seizure control. This narrative review provides an update on SUDEP.

Original language	English
Journal	Neurologic Clinics
Volume	40
Issue number	4
Pages (from-to)	741-754
Number of pages	14
ISSN	0733-8619
DOIs	https://doi.org/10.1016/j.ncl.2022.06.001
Publication status	Published - Nov 2022

Keywords

Epilepsy
Mortality
Seizure
Sudden unexpected death in epilepsy
SUDEP

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10.1016/j.ncl.2022.06.001

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title = "Update on Sudden Unexpected Death in Epilepsy",

abstract = "Persons with epilepsy (PWE) have an up to 34-fold increased risk of dying suddenly and unexpectedly compared with the general population. Despite being potentially preventable by optimal care, sudden unexpected death in epilepsy (SUDEP) is one of the most frequent causes of death in PWE, especially in children and younger adults. The incidence of SUDEP in the general epilepsy population is rather consistent at 1.2 to 1.3 per 1000 person-year across series. Several risk factors for SUDEP have been identified, but with focal-to-bilateral or generalized tonic-clonic seizures and sleeping alone as the most significant. Thereby, optimal care and nocturnal surveillance might decrease the risk of SUDEP. Finally, PWE wants information about SUDEP, and providing this information might increase adherence to the treatment and thereby good seizure control. This narrative review provides an update on SUDEP.",

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T1 - Update on Sudden Unexpected Death in Epilepsy

AU - Kløvgaard, Marius

AU - Sabers, Anne

AU - Ryvlin, Philippe

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N2 - Persons with epilepsy (PWE) have an up to 34-fold increased risk of dying suddenly and unexpectedly compared with the general population. Despite being potentially preventable by optimal care, sudden unexpected death in epilepsy (SUDEP) is one of the most frequent causes of death in PWE, especially in children and younger adults. The incidence of SUDEP in the general epilepsy population is rather consistent at 1.2 to 1.3 per 1000 person-year across series. Several risk factors for SUDEP have been identified, but with focal-to-bilateral or generalized tonic-clonic seizures and sleeping alone as the most significant. Thereby, optimal care and nocturnal surveillance might decrease the risk of SUDEP. Finally, PWE wants information about SUDEP, and providing this information might increase adherence to the treatment and thereby good seizure control. This narrative review provides an update on SUDEP.

AB - Persons with epilepsy (PWE) have an up to 34-fold increased risk of dying suddenly and unexpectedly compared with the general population. Despite being potentially preventable by optimal care, sudden unexpected death in epilepsy (SUDEP) is one of the most frequent causes of death in PWE, especially in children and younger adults. The incidence of SUDEP in the general epilepsy population is rather consistent at 1.2 to 1.3 per 1000 person-year across series. Several risk factors for SUDEP have been identified, but with focal-to-bilateral or generalized tonic-clonic seizures and sleeping alone as the most significant. Thereby, optimal care and nocturnal surveillance might decrease the risk of SUDEP. Finally, PWE wants information about SUDEP, and providing this information might increase adherence to the treatment and thereby good seizure control. This narrative review provides an update on SUDEP.

KW - Epilepsy

KW - Mortality

KW - Seizure

KW - Sudden unexpected death in epilepsy

KW - SUDEP

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DO - 10.1016/j.ncl.2022.06.001

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JO - Neurologic Clinics

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Update on Sudden Unexpected Death in Epilepsy

Abstract

Keywords

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