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uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion

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  1. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability

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  2. Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins

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  3. Comparison of two different culture conditions for derivation of early hiPSC

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  4. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway

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  5. Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery

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  1. Personalized B cell response to the Lactobacillus rhamnosus GG probiotic in healthy human subjects: a randomized trial

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  2. Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis

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  3. The collagen receptor uPARAP/Endo180 regulates collectins through unique structural elements in its FNII domain

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  4. Cellular uptake of collagens and implications for immune cell regulation in disease

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  5. TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding

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The uptake and lysosomal degradation of collagen by fibroblasts constitute a major pathway in the turnover of connective tissue. However, the molecular mechanisms governing this pathway are poorly understood. Here, we show that the urokinase plasminogen activator receptor-associated protein (uPARAP)/Endo180, a novel mesenchymally expressed member of the macrophage mannose receptor family of endocytic receptors, is a key player in this process. Fibroblasts from mice with a targeted deletion in the uPARAP/Endo180 gene displayed a near to complete abrogation of collagen endocytosis. Furthermore, these cells had diminished initial adhesion to a range of different collagens, as well as impaired migration on fibrillar collagen. These studies identify a central function of uPARAP/Endo180 in cellular collagen interactions.

Original languageEnglish
JournalJournal of Cell Biology
Volume160
Issue number7
Pages (from-to)1009-15
Number of pages7
ISSN0021-9525
DOIs
Publication statusPublished - 31 Mar 2003

    Research areas

  • Animals, Cell Adhesion, Cell Movement, Cells, Cultured, Collagen, Collagenases, Endocytosis, Fibroblasts, Fibronectins, Gene Deletion, Matrix Metalloproteinase 13, Membrane Glycoproteins, Mice, Receptors, Cell Surface, Receptors, Mitogen, Receptors, Urokinase Plasminogen Activator, Transferrin

ID: 46435589