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Unsulfated cholecystokinin: An overlooked hormone?

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  1. Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors

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  2. Natriuretic peptides and cerebral hemodynamics

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  3. Adropin: a new regulatory peptide in cardiovascular endocrinology

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  4. Cardiac C-type natriuretic peptide gene expression and plasma concentrations in neonatal piglets

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  5. Gut hormones - Team workers or solo trippers?

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  1. Oral D/L-3-Hydroxybutyrate stimulates cholecystokinin and insulin secretion and slows gastric emptying in healthy males

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  2. Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy

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  3. Circadian variations in plasma concentrations of cholecystokinin and gastrin in man

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  4. Increased oral sodium chloride intake in humans amplifies selectively postprandial GLP-1 but not GIP, CCK, and gastrin in plasma

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Tyrosyl O-sulfation is a common posttranslational derivatization of proteins that may also modify regulatory peptides. Among these are members of the cholecystokinin (CCK)/gastrin family. While sulfation of gastrin peptides is without effect on the bioactivity, O-sulfation is crucial for the cholecystokinetic activity (i.e. gallbladder emptying) of CCK peptides. Accordingly, the purification of CCK as a sulfated peptide was originally monitored by its gallbladder emptying effect. Since then, the dogma has prevailed that CCK peptides are always sulfated. The dogma is correct in a semantic context since the gallbladder expresses only the CCK-A receptor that requires sulfation of the ligand. CCK peptides, however, are also ligands for the CCK-B receptors that do not require ligand sulfation. Consequently, unsulfated CCK peptides may act via CCK-B receptors. Since in vivo occurrence of unsulfated products of proCCK with an intact α-amidated C-terminal tetrapeptide sequence (-Trp-Met-Asp-PheNH(2)) has been reported, it is likely that unsulfated CCK peptides constitute a separate hormone system that acts via CCK-B receptors. This review discusses the occurrence, molecular forms, and possible physiological as well as pathophysiological significance of unsulfated CCK peptides.
Original languageEnglish
JournalRegulatory Peptides
Volume173
Issue number1-3
Pages (from-to)1-5
Number of pages5
ISSN0167-0115
DOIs
Publication statusPublished - 2012

    Research areas

  • Amino Acid Sequence, Animals, Cholecystokinin, Gene Expression, Humans, Molecular Sequence Data, Organ Specificity, Protein Isoforms, Protein Processing, Post-Translational, Receptors, Cholecystokinin, Signal Transduction, Tyrosine

ID: 36789524