Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Unit policies regarding tocolysis after preterm premature rupture of membranes: association with latency, neonatal and 2-year outcomes (EPICE cohort)

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Infants with congenital heart defects have reduced brain volumes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. In vitro efficacy of artemisinin-based treatments against SARS-CoV-2

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Low-dose aspirin for primary and secondary prevention of cardiovascular events in Denmark 1998-2018

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Oral pre‑treatment with thiocyanate (SCN−) protects against myocardial ischaemia–reperfusion injury in rats

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Data concerning the Copenhagen tool: A research tool for evaluation of basic life Support educational interventions

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Determinants of Bacille Calmette-Guérin scarification in Danish children

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Magnesium sulphate treatment decreases the risk of cerebral palsy after preterm birth

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The Copenhagen Tool A research tool for evaluation of Basic Life Support educational interventions

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. No long-term effect of oral stimulation on the intra-oral vacuum in healthy premature infants

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

After preterm premature rupture of membranes (PPROM), antibiotics and antenatal steroids are effective evidence-based interventions, but the use of tocolysis is controversial. We investigated whether a unit policy of tocolysis use after PPROM is associated with prolonged gestation and improved outcomes for very preterm infants in units that systematically use these other evidence-based treatments. From the prospective, observational, population-based EPICE cohort study (all very preterm births in 19 regions from 11 European countries, 2011-2012), we included 607 women with a singleton pregnancy and PPROM at 24-29 weeks' gestation, of whom 101, 195 and 311 were respectively managed in 17, 32 and 45 units with no-use, restricted and liberal tocolysis policies for PPROM. The association between unit policies and outcomes (early-onset sepsis, survival at discharge, survival at discharge without severe morbidity and survival at two years without gross motor impairment) was investigated using three-level random-intercept logistic regression models, showing no differences in neonatal or two-year outcomes by unit policy. Moreover, there was no association between unit policies and prolongation of gestation in a multilevel survival analysis. Compared to a unit policy of no-use of tocolysis after PPROM, a liberal or restricted policy is not associated with improved obstetric, neonatal or two-year outcomes.

Original languageEnglish
Article number9535
JournalScientific Reports
Volume10
Issue number1
ISSN2045-2322
DOIs
Publication statusPublished - 12 Jun 2020

ID: 60052740