Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Unexpected, isolated activated partial thromboplastin time prolongation: A practical mini-review

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Reference values for the EORTC QLQ-C30 in patients with advanced stage Hodgkin Lymphoma and in Hodgkin Lymphoma survivors

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Vitamin E and acute graft-versus-host disease after myeloablative allogeneic hematopoietic cell transplantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Real-World Outcomes for 205 Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Neprilysin inhibition increases glucagon levels in humans and mice with potential effects on amino acid metabolism

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Mid-regional pro-atrial natriuretic peptide levels before and after hemodialysis predict long-term prognosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Intensive Lifestyle Intervention Increases Plasma Midregional Proatrial Natriuretic Peptide Concentrations in Overweight Children

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

A common inquiry in coagulation laboratories is how to interpret an unexpected, isolated prolonged activated partial thromboplastin time (APTT). In this context, isolated means together with a normal prothrombin time (PT) and/or normal international normalized ratio (INR). This finding may lead to contact with laboratory doctors for further advice on a diagnostic strategy. Occasionally, the need for a diagnostic algorithm can be subacute, where surgery has to be postponed until an explanation for the isolated, prolonged APTT has been established. Activated partial thromboplastin time as a coagulation test was developed to monitor patients with hemophilia. Different APTT reagents display considerable differences in their sensitivity to deficiencies of coagulation factors. An isolated, prolonged APTT is seen in (a) individuals/patients with lupus anticoagulants, (b) patients in treatment with anticoagulants, mainly heparin, and (c) patients with deficiencies of specific coagulation factors. In this tutorial review, we summarize what may cause an isolated prolonged APTT and we present a simple diagnostic algorithm to differentiate between lupus anticoagulants (common) and factor deficiencies (rare). The identification of an isolated prolonged APTT as well as the underlying cause can be of the utmost importance in ensuring the correct therapeutic follow-up.

Original languageEnglish
JournalEuropean Journal of Haematology
Volume104
Issue number6
Pages (from-to)519-525
Number of pages7
ISSN0902-4441
DOIs
Publication statusPublished - Jun 2020

    Research areas

  • activated partial thromboplastin time, hemophilia, lupus anticoagulants

ID: 59944104