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Uncovering a Role for the Dorsal Hippocampal Commissure in Recognition Memory

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Postans, M ; Parker, G D ; Lundell, H ; Ptito, M ; Hamandi, K ; Gray, W P ; Aggleton, J P ; Dyrby, T B ; Jones, D K ; Winter, M. / Uncovering a Role for the Dorsal Hippocampal Commissure in Recognition Memory. In: Cerebral Cortex. 2019.

Bibtex

@article{7114b50591e142029000c68f9d340703,
title = "Uncovering a Role for the Dorsal Hippocampal Commissure in Recognition Memory",
abstract = "The dorsal hippocampal commissure (DHC) is a white matter tract that provides interhemispheric connections between temporal lobe brain regions. Despite the importance of these regions for learning and memory, there is scant evidence of a role for the DHC in successful memory performance. We used diffusion-weighted magnetic resonance imaging (DW-MRI) and white matter tractography to reconstruct the DHC in both humans (in vivo) and nonhuman primates (ex vivo). Across species, our findings demonstrate a close consistency between the known anatomy and tract reconstructions of the DHC. Anterograde tract-tracer techniques also highlighted the parahippocampal origins of DHC fibers in nonhuman primates. Finally, we derived diffusion tensor MRI metrics from the DHC in a large sample of human subjects to investigate whether interindividual variation in DHC microstructure is predictive of memory performance. The mean diffusivity of the DHC correlated with performance in a standardized recognition memory task, an effect that was not reproduced in a comparison commissure tract-the anterior commissure. These findings highlight a potential role for the DHC in recognition memory, and our tract reconstruction approach has the potential to generate further novel insights into the role of this previously understudied white matter tract in both health and disease.",
author = "M Postans and Parker, {G D} and H Lundell and M Ptito and K Hamandi and Gray, {W P} and Aggleton, {J P} and Dyrby, {T B} and Jones, {D K} and M Winter",
note = "{\circledC} The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2019",
month = "7",
day = "29",
doi = "10.1093/cercor/bhz143",
language = "English",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Uncovering a Role for the Dorsal Hippocampal Commissure in Recognition Memory

AU - Postans, M

AU - Parker, G D

AU - Lundell, H

AU - Ptito, M

AU - Hamandi, K

AU - Gray, W P

AU - Aggleton, J P

AU - Dyrby, T B

AU - Jones, D K

AU - Winter, M

N1 - © The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2019/7/29

Y1 - 2019/7/29

N2 - The dorsal hippocampal commissure (DHC) is a white matter tract that provides interhemispheric connections between temporal lobe brain regions. Despite the importance of these regions for learning and memory, there is scant evidence of a role for the DHC in successful memory performance. We used diffusion-weighted magnetic resonance imaging (DW-MRI) and white matter tractography to reconstruct the DHC in both humans (in vivo) and nonhuman primates (ex vivo). Across species, our findings demonstrate a close consistency between the known anatomy and tract reconstructions of the DHC. Anterograde tract-tracer techniques also highlighted the parahippocampal origins of DHC fibers in nonhuman primates. Finally, we derived diffusion tensor MRI metrics from the DHC in a large sample of human subjects to investigate whether interindividual variation in DHC microstructure is predictive of memory performance. The mean diffusivity of the DHC correlated with performance in a standardized recognition memory task, an effect that was not reproduced in a comparison commissure tract-the anterior commissure. These findings highlight a potential role for the DHC in recognition memory, and our tract reconstruction approach has the potential to generate further novel insights into the role of this previously understudied white matter tract in both health and disease.

AB - The dorsal hippocampal commissure (DHC) is a white matter tract that provides interhemispheric connections between temporal lobe brain regions. Despite the importance of these regions for learning and memory, there is scant evidence of a role for the DHC in successful memory performance. We used diffusion-weighted magnetic resonance imaging (DW-MRI) and white matter tractography to reconstruct the DHC in both humans (in vivo) and nonhuman primates (ex vivo). Across species, our findings demonstrate a close consistency between the known anatomy and tract reconstructions of the DHC. Anterograde tract-tracer techniques also highlighted the parahippocampal origins of DHC fibers in nonhuman primates. Finally, we derived diffusion tensor MRI metrics from the DHC in a large sample of human subjects to investigate whether interindividual variation in DHC microstructure is predictive of memory performance. The mean diffusivity of the DHC correlated with performance in a standardized recognition memory task, an effect that was not reproduced in a comparison commissure tract-the anterior commissure. These findings highlight a potential role for the DHC in recognition memory, and our tract reconstruction approach has the potential to generate further novel insights into the role of this previously understudied white matter tract in both health and disease.

U2 - 10.1093/cercor/bhz143

DO - 10.1093/cercor/bhz143

M3 - Journal article

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

ER -

ID: 57715389