TY - JOUR
T1 - Uncoupling of collagen II metabolism in newly diagnosed, untreated rheumatoid arthritis is linked to inflammation and antibodies against cyclic citrullinated peptides
AU - Christensen, Anne Friesgaard
AU - Hørslev-Petersen, Kim
AU - Christgau, Stephan
AU - Lindegaard, Hanne Merete
AU - Lottenburger, Tine
AU - Junker, Kirsten
AU - Hetland, Merete Lund
AU - Stengaard-Pedersen, Kristian
AU - Jacobsen, Søren
AU - Ellingsen, Torkell
AU - Andersen, Lis Smedegaard
AU - Hansen, Ib
AU - Skjødt, Henrik
AU - Pedersen, Jens Kristian
AU - Lauridsen, Ulrik Birk
AU - Svendsen, Anders Jørgen
AU - Tarp, Ulrik
AU - Pødenphanth, Jan
AU - Heegaard, Niels H H
AU - Vestergaard, Aage
AU - Jurik, Anne Grethe
AU - Østergaard, Mikkel
AU - Junker, Peter
PY - 2010
Y1 - 2010
N2 - Objective. To investigate the relationship between markers of collagen 11 synthesis and degradation with disease activity measures, autoantibodies, and radiographic outcomes in a 4-year protocol on patients with early rheumatoid arthritis (RA) who are naive to disease-modifying antirheumatic drugs. Methods. One hundred sixty patients with newly diagnosed, untreated RA entered the Cyclosporine, Methotrexate, Steroid in RA (CIMESTRA) trial. Disease activity and radiograph status were measured at baseline and 4 years. The N-terminal propeptide of collagen IIA (PIIANP) and the crosslinked C-telopeptide of collagen II (CTX-II) were quantified at baseline by ELISA. PIIANP was also assayed at 2 and 4 years. Anticyclic citrullinated peptide (anti-CCP) was recorded at baseline. An uncoupling index for cartilage collagen metabolism was calculated from PHANP and CTX-II measurements. Results. PIIANP was low at diagnosis and 4 years on (p
AB - Objective. To investigate the relationship between markers of collagen 11 synthesis and degradation with disease activity measures, autoantibodies, and radiographic outcomes in a 4-year protocol on patients with early rheumatoid arthritis (RA) who are naive to disease-modifying antirheumatic drugs. Methods. One hundred sixty patients with newly diagnosed, untreated RA entered the Cyclosporine, Methotrexate, Steroid in RA (CIMESTRA) trial. Disease activity and radiograph status were measured at baseline and 4 years. The N-terminal propeptide of collagen IIA (PIIANP) and the crosslinked C-telopeptide of collagen II (CTX-II) were quantified at baseline by ELISA. PIIANP was also assayed at 2 and 4 years. Anticyclic citrullinated peptide (anti-CCP) was recorded at baseline. An uncoupling index for cartilage collagen metabolism was calculated from PHANP and CTX-II measurements. Results. PIIANP was low at diagnosis and 4 years on (p
UR - https://www.scopus.com/pages/publications/77953208549
U2 - 10.3899/jrheum.091265
DO - 10.3899/jrheum.091265
M3 - Journal article
C2 - 20436079
SN - 0315-162X
VL - 37
SP - 1113
EP - 1120
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 6
ER -