Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Unaffected bone mineral density in Danish children and adolescents with type 1 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Adults with pathogenic MC4R mutations have increased final height and thereby increased bone mass

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Characterization of osteoclasts derived from CD14+ monocytes isolated from peripheral blood

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Interleukin-6 may not affect bone resorption marker CTX or bone formation marker P1NP in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Hypophosphatemic Hypovitaminosis D induces Osteomalacia in the adult female rat

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Aims: Adults with type 1 diabetes mellitus (T1D) have decreased bone mineral density (BMD). Our study aimed at determining BMD and the association to metabolic control in children and adolescents with T1D. Methods: 244 patients (113 girls) with a median age of 14.3 years and T1D duration of 1–16 years were included. A dual-energy X-ray absorptiometry scan assessed BMD Z-scores excluding the head (total body less head, TBLH). TBLH-BMD were then investigated for associations to diabetes relevant variables such as HbA1c, insulin treatment, anthropometry and physical activity. Results: In all participants the TBLH-BMD Z-score (0.22 ± 0.96) was significantly higher than the references. Separated by sex, TBLH-BMD Z-score in boys (0.11 ± 0.84) was no different from healthy peers whereas TBLH-BMD Z-score was significantly higher in girls (0.36 ± 1.09). The higher TBLH-BMD Z-score in girls were explained by higher BMI Z-scores. Participants with assumed final height (based on age) had an average TBLH-BMD Z-score of 0.78 ± 1.06, significantly higher than references independent of gender, HbA1c, height- and weight Z-scores. Multiple regression analyses showed that TBLH BMD Z-score associated negatively to HbA1c (P = 0.003), pump treatment (P = 0.019) and screen-time (P = 0.005) and positively to weight Z-score (P < 0.001). Physical activity, sex and puberty did not significantly associate to TBLH-BMD Z-score. Conclusion: Unlike adults with T1D, BMD is not decreased in children and adolescents with T1D and even elevated after attained final height. As HbA1c negatively associates to BMD, decreased BMD may progress over time. Whether changes in microarchitecture or bone metabolism precede changes in BMD needs further investigation.

Original languageEnglish
JournalJournal of Bone and Mineral Metabolism
Volume38
Issue number3
Pages (from-to)328-337
Number of pages10
ISSN0914-8779
DOIs
Publication statusPublished - May 2020

    Research areas

  • Bone mineral density, HbA1c, Pediatrics, Type 1 diabetes mellitus, Humans, Bone Density/physiology, Child, Preschool, Infant, Male, Absorptiometry, Photon, Diabetes Mellitus, Type 1/diagnostic imaging, Regression Analysis, Exercise, Adolescent, Denmark, Adult, Female, Health Status, Child

ID: 58435634