Umbilical cord mesenchymal stromal cells-from bench to bedside

Shashank Chetty*, Reza Yarani, Ganesh Swaminathan, Rosita Primavera, Skobha Regmi, Sravanthi Rai, Jim Zhong, Abantika Ganguly, Avnesh S Thakor

*Corresponding author for this work

Abstract

In recent years, mesenchymal stromal cells (MSCs) have generated a lot of attention due to their paracrine and immuno-modulatory properties. mesenchymal stromal cells derived from the umbilical cord (UC) are becoming increasingly recognized as having increased therapeutic potential when compared to mesenchymal stromal cells from other sources. The purpose of this review is to provide an overview of the various compartments of umbilical cord tissue from which mesenchymal stromal cells can be isolated, the differences and similarities with respect to their regenerative and immuno-modulatory properties, as well as the single cell transcriptomic profiles of in vitro expanded and freshly isolated umbilical cord-mesenchymal stromal cells. In addition, we discuss the therapeutic potential and biodistribution of umbilical cord-mesenchymal stromal cells following systemic administration while providing an overview of pre-clinical and clinical trials involving umbilical cord-mesenchymal stromal cells and their associated secretome and extracellular vesicles (EVs). The clinical applications of umbilical cord-mesenchymal stromal cells are also discussed, especially in relation to obstacles and potential solutions for their effective translation from bench to bedside.

Original languageEnglish
Article number1006295
JournalFrontiers in Cell and Developmental Biology
Volume10
Pages (from-to)1006295
ISSN2296-634X
DOIs
Publication statusPublished - 12 Oct 2022

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