Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Ultrastructure of interstitial cells in subserosa of human colon

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Human P2X7 receptor causes cycle arrest in RPMI-8226 myeloma cells to alter the interaction with osteoblasts and osteoclasts

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. T-Cell Gene Therapy in Cancer Immunotherapy: Why It Is No Longer Just CARs on The Road

    Research output: Contribution to journalReviewResearchpeer-review

  3. Epigenetic Analysis of Circulating Tumor DNA in Localized and Metastatic Prostate Cancer: Evaluation of Clinical Biomarker Potential

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Long-term Consequences of Undiagnosed Celiac Seropositivity

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hypertensive nephropathy is associated with an increased risk of myeloma, skin, and renal cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The association of celiac disease and allergic disease in a general adult population

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
We studied the ultrastructure of interstitial cells in the subserosal/adventitial layer in human colon. An interstitial cell type with an ultrastructure intermediate between fibroblast-like cells (FLC) and interstitial cells of Cajal was identified (IC-SS). IC-SS had thin and flattened branching processes, most densely arranged close to the longitudinal muscle cells. Caveolae, bundles of intermediate filaments and membrane-associated dense bands, often with a patchy basal lamina, were characteristic. Secretory organelles (granular endoplasmic reticulum, smooth endoplasmic reticulum, Golgi, coated vesicles) were prominent. The IC-SS ultrastructure was different from that of FLC in the longitudinal layer, which had no caveolae and fewer intermediate filaments. Peg-and-socket junctions between IC-SS and between IC-SS and muscle cells were present, and IC-SS processes had close, selective appositions to muscle cells. Gap junctions were not observed. Small nerve bundles were abundant, but close contacts (
Original languageEnglish
JournalCells, Tissues, Organs
Volume197
Issue number4
Pages (from-to)322-32
Number of pages11
ISSN1422-6405
DOIs
Publication statusPublished - 2013

ID: 38695545