Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release

T Nielsen; Thomas Hempel Sparsø; Niels Grarup; T Jørgensen; C Pisinger; Daniel Rinse Witte; T Hansen; O Pedersen; DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium

doi:10.1007/s00125-011-2054-3

Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release

T Nielsen, Thomas Hempel Sparsø, Niels Grarup, T Jørgensen, C Pisinger, Daniel Rinse Witte, T Hansen, O Pedersen, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium

34 Citations (Scopus)

Abstract

By combining multiple genome-wide association (GWA) studies and comprehensive replication efforts, 12 novel type 2 diabetes associated loci have recently been discovered. Here we evaluate the effect of lead variants of these loci on estimates of insulin release and insulin resistance derived from an oral glucose tolerance test.

Original language	English
Journal	Diabetologia
Volume	54
Issue number	5
Pages (from-to)	1052-6
Number of pages	5
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-011-2054-3
Publication status	Published - 2011

Keywords

Adaptor Proteins, Signal Transducing
Adult
Alleles
Carrier Proteins
Cell Cycle Proteins
DNA-Binding Proteins
Diabetes Mellitus, Type 2
Dual-Specificity Phosphatases
Female
GTPase-Activating Proteins
Genome-Wide Association Study
Genotype
Glucose
Glucose Tolerance Test
HMGA2 Protein
Heat-Shock Proteins
Hepatocyte Nuclear Factor 1-alpha
Humans
Insulin
Insulin-Secreting Cells
KCNQ1 Potassium Channel
Male
Middle Aged
Mitogen-Activated Protein Kinase Phosphatases
Molecular Epidemiology
Nuclear Proteins
Sp Transcription Factors
Transcription Factors

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10.1007/s00125-011-2054-3

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title = "Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release",

abstract = "By combining multiple genome-wide association (GWA) studies and comprehensive replication efforts, 12 novel type 2 diabetes associated loci have recently been discovered. Here we evaluate the effect of lead variants of these loci on estimates of insulin release and insulin resistance derived from an oral glucose tolerance test.",

keywords = "Adaptor Proteins, Signal Transducing, Adult, Alleles, Carrier Proteins, Cell Cycle Proteins, DNA-Binding Proteins, Diabetes Mellitus, Type 2, Dual-Specificity Phosphatases, Female, GTPase-Activating Proteins, Genome-Wide Association Study, Genotype, Glucose, Glucose Tolerance Test, HMGA2 Protein, Heat-Shock Proteins, Hepatocyte Nuclear Factor 1-alpha, Humans, Insulin, Insulin-Secreting Cells, KCNQ1 Potassium Channel, Male, Middle Aged, Mitogen-Activated Protein Kinase Phosphatases, Molecular Epidemiology, Nuclear Proteins, Sp Transcription Factors, Transcription Factors",

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doi = "10.1007/s00125-011-2054-3",

language = "English",

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T1 - Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release

AU - Nielsen, T

AU - Sparsø, Thomas Hempel

AU - Grarup, Niels

AU - Jørgensen, T

AU - Pisinger, C

AU - Witte, Daniel Rinse

AU - Hansen, T

AU - Pedersen, O

AU - DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium

PY - 2011

Y1 - 2011

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AB - By combining multiple genome-wide association (GWA) studies and comprehensive replication efforts, 12 novel type 2 diabetes associated loci have recently been discovered. Here we evaluate the effect of lead variants of these loci on estimates of insulin release and insulin resistance derived from an oral glucose tolerance test.

KW - Adaptor Proteins, Signal Transducing

KW - Adult

KW - Alleles

KW - Carrier Proteins

KW - Cell Cycle Proteins

KW - DNA-Binding Proteins

KW - Diabetes Mellitus, Type 2

KW - Dual-Specificity Phosphatases

KW - Female

KW - GTPase-Activating Proteins

KW - Genome-Wide Association Study

KW - Genotype

KW - Glucose

KW - Glucose Tolerance Test

KW - HMGA2 Protein

KW - Heat-Shock Proteins

KW - Hepatocyte Nuclear Factor 1-alpha

KW - Humans

KW - Insulin

KW - Insulin-Secreting Cells

KW - KCNQ1 Potassium Channel

KW - Male

KW - Middle Aged

KW - Mitogen-Activated Protein Kinase Phosphatases

KW - Molecular Epidemiology

KW - Nuclear Proteins

KW - Sp Transcription Factors

KW - Transcription Factors

U2 - 10.1007/s00125-011-2054-3

DO - 10.1007/s00125-011-2054-3

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SN - 0012-186X

VL - 54

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EP - 1056

JO - Diabetologia

JF - Diabetologia

IS - 5

ER -

Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release

Abstract

Keywords

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