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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group

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  1. Highlights in allergic contact dermatitis 2018/2019

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  2. Quality of life and disease severity in dermatitis patients with fragrance allergy-A cross-sectional European questionnaire study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Optimal patch test concentration for three widely used sensitizing fragrance substances without mandatory labelling in cosmetics

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Skin tape stripping: Which layers of the epidermis are removed?

    Research output: Contribution to journalJournal articleResearchpeer-review

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BACKGROUND: There is an ongoing discussion on whether routinely patch testing with p-phenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Late-appearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre-existing sensitization.

OBJECTIVES: To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD-DHC) in order to characterize reaction patterns concerning time and dose in PPD-sensitized individuals.

METHODS: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. There were then seven follow-up visits over a period of 28 days.

RESULTS: Twenty-six volunteers completed the study, of whom 23 of 26 (88%) reacted to PPD 1.0%, and 69% reacted to PPD 0.32%. Altogether, 42% and 27% reacted to the corresponding equimolar concentrations of PPD-DHC. After day 7, no new reactions were observed to any concentration tested, either of PPD or of PPD-DHC.

CONCLUSION: No late-appearing reactions to PPD or PPD-DHC were observed at any dose. There is a risk of missing contact allergy when the dose is decreased.

Original languageEnglish
JournalContact Dermatitis
Volume81
Issue number1
Pages (from-to)1-8
Number of pages8
ISSN0105-1873
DOIs
Publication statusPublished - Jul 2019

ID: 57654925