Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group

Ewa Young; Klaus E Andersen; Magnus Bruze; Ana Giménez-Arnau; Katrine Ross-Hansen; Jeanne D Johansen; Jakob Torp Madsen; Erik Zimerson; Cecilia Svedman

doi:10.1111/cod.13235

Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group

Ewa Young, Klaus E Andersen, Magnus Bruze, Ana Giménez-Arnau, Katrine Ross-Hansen, Jeanne D Johansen, Jakob Torp Madsen, Erik Zimerson, Cecilia Svedman

9 Citations (Scopus)

Abstract

BACKGROUND: There is an ongoing discussion on whether routinely patch testing with p-phenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Late-appearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre-existing sensitization.

OBJECTIVES: To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD-DHC) in order to characterize reaction patterns concerning time and dose in PPD-sensitized individuals.

METHODS: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. There were then seven follow-up visits over a period of 28 days.

RESULTS: Twenty-six volunteers completed the study, of whom 23 of 26 (88%) reacted to PPD 1.0%, and 69% reacted to PPD 0.32%. Altogether, 42% and 27% reacted to the corresponding equimolar concentrations of PPD-DHC. After day 7, no new reactions were observed to any concentration tested, either of PPD or of PPD-DHC.

CONCLUSION: No late-appearing reactions to PPD or PPD-DHC were observed at any dose. There is a risk of missing contact allergy when the dose is decreased.

Original language	English
Journal	Contact Dermatitis
Volume	81
Issue number	1
Pages (from-to)	1-8
Number of pages	8
ISSN	0105-1873
DOIs	https://doi.org/10.1111/cod.13235
Publication status	Published - 1 Jul 2019

Keywords

active sensitization
allergic contact dermatitis
contact allergy
delayed
dilution series
false-negative reactions
hypersensitivity
late-appearing patch test reactions
PPD

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Young, E., Andersen, K. E., Bruze, M., Giménez-Arnau, A., Ross-Hansen, K., Johansen, J. D., Madsen, J. T., Zimerson, E., & Svedman, C. (2019). Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group. Contact Dermatitis, 81(1), 1-8. https://doi.org/10.1111/cod.13235

Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group. / Young, Ewa; Andersen, Klaus E; Bruze, Magnus et al.
In: Contact Dermatitis, Vol. 81, No. 1, 01.07.2019, p. 1-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Young, E, Andersen, KE, Bruze, M, Giménez-Arnau, A, Ross-Hansen, K, Johansen, JD, Madsen, JT, Zimerson, E & Svedman, C 2019, 'Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group', Contact Dermatitis, vol. 81, no. 1, pp. 1-8. https://doi.org/10.1111/cod.13235

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title = "Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group",

abstract = "BACKGROUND: There is an ongoing discussion on whether routinely patch testing with p-phenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Late-appearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre-existing sensitization.OBJECTIVES: To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD-DHC) in order to characterize reaction patterns concerning time and dose in PPD-sensitized individuals.METHODS: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. There were then seven follow-up visits over a period of 28 days.RESULTS: Twenty-six volunteers completed the study, of whom 23 of 26 (88%) reacted to PPD 1.0%, and 69% reacted to PPD 0.32%. Altogether, 42% and 27% reacted to the corresponding equimolar concentrations of PPD-DHC. After day 7, no new reactions were observed to any concentration tested, either of PPD or of PPD-DHC.CONCLUSION: No late-appearing reactions to PPD or PPD-DHC were observed at any dose. There is a risk of missing contact allergy when the dose is decreased.",

keywords = "active sensitization, allergic contact dermatitis, contact allergy, delayed, dilution series, false-negative reactions, hypersensitivity, late-appearing patch test reactions, PPD",

author = "Ewa Young and Andersen, {Klaus E} and Magnus Bruze and Ana Gim{\'e}nez-Arnau and Katrine Ross-Hansen and Johansen, {Jeanne D} and Madsen, {Jakob Torp} and Erik Zimerson and Cecilia Svedman",

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T2 - A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group

AU - Young, Ewa

AU - Andersen, Klaus E

AU - Bruze, Magnus

AU - Giménez-Arnau, Ana

AU - Ross-Hansen, Katrine

AU - Johansen, Jeanne D

AU - Madsen, Jakob Torp

AU - Zimerson, Erik

AU - Svedman, Cecilia

PY - 2019/7/1

Y1 - 2019/7/1

N2 - BACKGROUND: There is an ongoing discussion on whether routinely patch testing with p-phenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Late-appearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre-existing sensitization.OBJECTIVES: To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD-DHC) in order to characterize reaction patterns concerning time and dose in PPD-sensitized individuals.METHODS: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. There were then seven follow-up visits over a period of 28 days.RESULTS: Twenty-six volunteers completed the study, of whom 23 of 26 (88%) reacted to PPD 1.0%, and 69% reacted to PPD 0.32%. Altogether, 42% and 27% reacted to the corresponding equimolar concentrations of PPD-DHC. After day 7, no new reactions were observed to any concentration tested, either of PPD or of PPD-DHC.CONCLUSION: No late-appearing reactions to PPD or PPD-DHC were observed at any dose. There is a risk of missing contact allergy when the dose is decreased.

AB - BACKGROUND: There is an ongoing discussion on whether routinely patch testing with p-phenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Late-appearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre-existing sensitization.OBJECTIVES: To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD-DHC) in order to characterize reaction patterns concerning time and dose in PPD-sensitized individuals.METHODS: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. There were then seven follow-up visits over a period of 28 days.RESULTS: Twenty-six volunteers completed the study, of whom 23 of 26 (88%) reacted to PPD 1.0%, and 69% reacted to PPD 0.32%. Altogether, 42% and 27% reacted to the corresponding equimolar concentrations of PPD-DHC. After day 7, no new reactions were observed to any concentration tested, either of PPD or of PPD-DHC.CONCLUSION: No late-appearing reactions to PPD or PPD-DHC were observed at any dose. There is a risk of missing contact allergy when the dose is decreased.

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KW - allergic contact dermatitis

KW - contact allergy

KW - delayed

KW - dilution series

KW - false-negative reactions

KW - hypersensitivity

KW - late-appearing patch test reactions

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DO - 10.1111/cod.13235

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SN - 0105-1873

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ER -

Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group

Abstract

Keywords

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