Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Twelve-hour brain lithium concentration in lithium maintenance treatment of manic-depressive disorder: daily versus alternate-day dosing schedule.

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Correction to: Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring vervet monkeys

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Three weeks of SSRI administration enhances the visual perceptual threshold - a randomized placebo-controlled study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Tryptophan depletion affects compulsive behaviour in rats: strain dependent effects and associated neuromechanisms

    Research output: Contribution to journalJournal articleResearchpeer-review

  • H.V. Jensen
  • P Plenge
  • A Stensgaard
  • E.T. Mellerup
  • C Thomsen
  • H Aggernæs
  • O Henriksen
View graph of relations
The 12-h brain lithium concentration was measured by lithium-7 magnetic resonance spectroscopy in ten manic-depressive patients receiving daily or alternate-day lithium carbonate treatment. The median dose of lithium carbonate was 800 mg in the daily treatment group and 1200 mg in the alternate-day group. Median 12-h serum lithium concentration in the two groups was 0.86 mmol l-1 and 0.55 mmol l-1, respectively, while the corresponding concentration in brain was 0.67 mmol l-1 and 0.52 mmol l-1, respectively. The 12-h brain lithium concentration was independent of lithium dosing schedule (multiple linear regression), but correlated significantly with the 12-h serum lithium concentration (P = 0.003; B = 0.53, 95% c.l. 0.24-0.82; beta = 0.83). Thus at identical 12-h serum lithium concentrations the 12-h brain lithium concentration is similar with both treatment regimes. As the risk of manic-depressive relapse during alternate-day lithium treatment is in our experience 3-fold greater than with daily treatment (at similar mean 12-h serum lithium concentration), the findings suggest that the difference in the prophylactic efficacy of the two dosing schedules is unrelated to differences in the 12-h brain lithium concentration
Original languageEnglish
JournalPsychopharmacology
Volume124
Issue number3
Pages (from-to)275-278
Publication statusPublished - 1996

ID: 32543627