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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Tumour-infiltrating lymphocyte scores effectively stratify outcomes over and above p16 post chemo-radiotherapy in anal cancer

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DOI

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BACKGROUND: The majority (90%) of anal cancers are human papillomavirus (HPV)-driven, identified using immunochemistry for p16. Compared with HPV- patients, those with HPV+ disease generally show improved survival, although relapse rates around 25% indicate a need for further stratification of this group.

METHODS: Using two cohorts of anal cancer, previously characterised for p16, we assessed the prognostic value of tumour-infiltrating lymphocytes (TILs).

RESULTS: Tumour-infiltrating lymphocyte scores were used to stratify p16+ cases, where tumours with absent/low levels of TIL had a relapse-free rate of 63%, as opposed to 92% with high levels of TIL (log rank P=0.006).

CONCLUSIONS: Assessment of TIL adds to p16 status in the prognosis of anal cancer following chemo-radiotherapy and provides evidence of the clinical importance of the immune response.

Original languageEnglish
JournalB J C
Volume114
Issue number2
Pages (from-to)134-7
Number of pages4
ISSN0007-0920
DOIs
Publication statusPublished - 19 Jan 2016

    Research areas

  • Anus Neoplasms, Carcinoma, Squamous Cell, Chemoradiotherapy, Cohort Studies, Disease-Free Survival, Female, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Lymphocytes, Tumor-Infiltrating, Male, Neoplasm Proteins, Papillomavirus Infections, Prognosis, Treatment Outcome, Journal Article, Research Support, Non-U.S. Gov't

ID: 49673909