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Tumour-infiltrating CD4-, CD8- and FOXP3-positive immune cells as predictive markers of mortality in BRCA1- and BRCA2-associated breast cancer

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Jørgensen, N., Hviid, T. V. F., Nielsen, L. B., Sønderstrup, I. M. H., Eriksen, J. O., Ejlertsen, B., Gerdes, A-M., Kruse, T. A., Thomassen, M., Jensen, M-B., & Lænkholm, A-V. (2021). Tumour-infiltrating CD4-, CD8- and FOXP3-positive immune cells as predictive markers of mortality in BRCA1- and BRCA2-associated breast cancer. British Journal of Cancer, 125(10), 1388-1398. https://doi.org/10.1038/s41416-021-01514-7

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Jørgensen, Nanna ; Hviid, Thomas Vauvert F ; Nielsen, Lise B ; Sønderstrup, Ida M H ; Eriksen, Jens Ole ; Ejlertsen, Bent ; Gerdes, Anne-Marie ; Kruse, Torben A ; Thomassen, Mads ; Jensen, Maj-Britt ; Lænkholm, Anne-Vibeke. / Tumour-infiltrating CD4-, CD8- and FOXP3-positive immune cells as predictive markers of mortality in BRCA1- and BRCA2-associated breast cancer. In: British Journal of Cancer. 2021 ; Vol. 125, No. 10. pp. 1388-1398.

Bibtex

@article{9ad4a9f2fe554dcab0745cabe538303a,
title = "Tumour-infiltrating CD4-, CD8- and FOXP3-positive immune cells as predictive markers of mortality in BRCA1- and BRCA2-associated breast cancer",
abstract = "BACKGROUND: The prognostic value of tumour-infiltrating lymphocytes (TILs) in breast cancer is well-established. However, the investigation of specific T-cell subsets exclusively in BRCA-associated breast cancer is sparse.METHODS: Tumour tissues from 414 BRCA-mutated breast cancer patients were analysed by immunohistochemistry and digital image analysis for expression of CD4, CD8 and FOXP3 immune markers. Distribution of CD4-, CD8- and FOXP3-positive cells and clinicopathological characteristics were assessed according to groups of low or high expression. The prognostic value was evaluated as continuous variables in univariate and multivariate analyses of overall survival and disease-free survival.RESULTS: Both CD4 and CD8 expression are associated with histological diagnosis, tumour grade and oestrogen and progesterone receptor expression status. CD4 expression is associated with BRCA gene status. A high percentage of tumour-infiltrating CD4-, CD8- or FOXP3-positive cells is significantly associated with lower mortality in BRCA1- and BRCA2-associated breast cancer and CD8-positive cells are associated with disease-free survival. No heterogeneity according to BRCA gene status was found for the prognostic value of the immune markers.CONCLUSIONS: The results support a prognostic role of specific T-cell subsets in BRCA-associated breast cancer and the promising potential of targeting the immune system in the treatment of these patients.",
author = "Nanna J{\o}rgensen and Hviid, {Thomas Vauvert F} and Nielsen, {Lise B} and S{\o}nderstrup, {Ida M H} and Eriksen, {Jens Ole} and Bent Ejlertsen and Anne-Marie Gerdes and Kruse, {Torben A} and Mads Thomassen and Maj-Britt Jensen and Anne-Vibeke L{\ae}nkholm",
note = "{\textcopyright} 2021. The Author(s), under exclusive licence to Springer Nature Limited.",
year = "2021",
month = nov,
doi = "10.1038/s41416-021-01514-7",
language = "English",
volume = "125",
pages = "1388--1398",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "10",

}

RIS

TY - JOUR

T1 - Tumour-infiltrating CD4-, CD8- and FOXP3-positive immune cells as predictive markers of mortality in BRCA1- and BRCA2-associated breast cancer

AU - Jørgensen, Nanna

AU - Hviid, Thomas Vauvert F

AU - Nielsen, Lise B

AU - Sønderstrup, Ida M H

AU - Eriksen, Jens Ole

AU - Ejlertsen, Bent

AU - Gerdes, Anne-Marie

AU - Kruse, Torben A

AU - Thomassen, Mads

AU - Jensen, Maj-Britt

AU - Lænkholm, Anne-Vibeke

N1 - © 2021. The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2021/11

Y1 - 2021/11

N2 - BACKGROUND: The prognostic value of tumour-infiltrating lymphocytes (TILs) in breast cancer is well-established. However, the investigation of specific T-cell subsets exclusively in BRCA-associated breast cancer is sparse.METHODS: Tumour tissues from 414 BRCA-mutated breast cancer patients were analysed by immunohistochemistry and digital image analysis for expression of CD4, CD8 and FOXP3 immune markers. Distribution of CD4-, CD8- and FOXP3-positive cells and clinicopathological characteristics were assessed according to groups of low or high expression. The prognostic value was evaluated as continuous variables in univariate and multivariate analyses of overall survival and disease-free survival.RESULTS: Both CD4 and CD8 expression are associated with histological diagnosis, tumour grade and oestrogen and progesterone receptor expression status. CD4 expression is associated with BRCA gene status. A high percentage of tumour-infiltrating CD4-, CD8- or FOXP3-positive cells is significantly associated with lower mortality in BRCA1- and BRCA2-associated breast cancer and CD8-positive cells are associated with disease-free survival. No heterogeneity according to BRCA gene status was found for the prognostic value of the immune markers.CONCLUSIONS: The results support a prognostic role of specific T-cell subsets in BRCA-associated breast cancer and the promising potential of targeting the immune system in the treatment of these patients.

AB - BACKGROUND: The prognostic value of tumour-infiltrating lymphocytes (TILs) in breast cancer is well-established. However, the investigation of specific T-cell subsets exclusively in BRCA-associated breast cancer is sparse.METHODS: Tumour tissues from 414 BRCA-mutated breast cancer patients were analysed by immunohistochemistry and digital image analysis for expression of CD4, CD8 and FOXP3 immune markers. Distribution of CD4-, CD8- and FOXP3-positive cells and clinicopathological characteristics were assessed according to groups of low or high expression. The prognostic value was evaluated as continuous variables in univariate and multivariate analyses of overall survival and disease-free survival.RESULTS: Both CD4 and CD8 expression are associated with histological diagnosis, tumour grade and oestrogen and progesterone receptor expression status. CD4 expression is associated with BRCA gene status. A high percentage of tumour-infiltrating CD4-, CD8- or FOXP3-positive cells is significantly associated with lower mortality in BRCA1- and BRCA2-associated breast cancer and CD8-positive cells are associated with disease-free survival. No heterogeneity according to BRCA gene status was found for the prognostic value of the immune markers.CONCLUSIONS: The results support a prognostic role of specific T-cell subsets in BRCA-associated breast cancer and the promising potential of targeting the immune system in the treatment of these patients.

UR - http://www.scopus.com/inward/record.url?scp=85112619521&partnerID=8YFLogxK

U2 - 10.1038/s41416-021-01514-7

DO - 10.1038/s41416-021-01514-7

M3 - Journal article

C2 - 34365471

VL - 125

SP - 1388

EP - 1398

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 10

ER -

ID: 67849645