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Tumour necrosis factor-alpha infusion produced insulin resistance but no change in the incretin effect in healthy volunteers

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@article{23a30bcb1731418eb902fa7cc6481a89,
title = "Tumour necrosis factor-alpha infusion produced insulin resistance but no change in the incretin effect in healthy volunteers",
abstract = "Type 2 diabetes mellitus (T2DM) is associated with peripheral insulin resistance, impaired incretin effect, and increased plasma levels of tumour necrosis factor-alpha (TNF-α). Although TNF-α infusion at a dose that induces systemic inflammation in healthy volunteers has been demonstrated to induce peripheral insulin resistance, the influence of this cytokine on the incretin effect is unknown.",
author = "Nielsen, {Signe Tellerup} and Louise Lehrskov-Schmidt and Rikke Krogh-Madsen and Solomon, {Thomas P J} and Lars Lehrskov-Schmidt and Holst, {Jens Juul} and Kirsten M{\o}ller",
note = "Copyright {\textcopyright} 2013 John Wiley & Sons, Ltd.",
year = "2013",
month = nov,
doi = "10.1002/dmrr.2441",
language = "English",
volume = "29",
pages = "655--63",
journal = "Diabetes - Metabolism: Research and Reviews",
issn = "1520-7552",
publisher = "John/Wiley & Sons Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - Tumour necrosis factor-alpha infusion produced insulin resistance but no change in the incretin effect in healthy volunteers

AU - Nielsen, Signe Tellerup

AU - Lehrskov-Schmidt, Louise

AU - Krogh-Madsen, Rikke

AU - Solomon, Thomas P J

AU - Lehrskov-Schmidt, Lars

AU - Holst, Jens Juul

AU - Møller, Kirsten

N1 - Copyright © 2013 John Wiley & Sons, Ltd.

PY - 2013/11

Y1 - 2013/11

N2 - Type 2 diabetes mellitus (T2DM) is associated with peripheral insulin resistance, impaired incretin effect, and increased plasma levels of tumour necrosis factor-alpha (TNF-α). Although TNF-α infusion at a dose that induces systemic inflammation in healthy volunteers has been demonstrated to induce peripheral insulin resistance, the influence of this cytokine on the incretin effect is unknown.

AB - Type 2 diabetes mellitus (T2DM) is associated with peripheral insulin resistance, impaired incretin effect, and increased plasma levels of tumour necrosis factor-alpha (TNF-α). Although TNF-α infusion at a dose that induces systemic inflammation in healthy volunteers has been demonstrated to induce peripheral insulin resistance, the influence of this cytokine on the incretin effect is unknown.

U2 - 10.1002/dmrr.2441

DO - 10.1002/dmrr.2441

M3 - Journal article

C2 - 23904405

VL - 29

SP - 655

EP - 663

JO - Diabetes - Metabolism: Research and Reviews

JF - Diabetes - Metabolism: Research and Reviews

SN - 1520-7552

IS - 8

ER -

ID: 42239672