Tumour-infiltrating lymphocyte scores effectively stratify outcomes over and above p16 post chemo-radiotherapy in anal cancer

Duncan C Gilbert, Eva Serup-Hansen, Dorte Linnemann, Estrid Høgdall, Charles Bailey, Jeff Summers, Hanne Havsteen, Gareth J Thomas

65 Citations (Scopus)

Abstract

BACKGROUND: The majority (90%) of anal cancers are human papillomavirus (HPV)-driven, identified using immunochemistry for p16. Compared with HPV- patients, those with HPV+ disease generally show improved survival, although relapse rates around 25% indicate a need for further stratification of this group.

METHODS: Using two cohorts of anal cancer, previously characterised for p16, we assessed the prognostic value of tumour-infiltrating lymphocytes (TILs).

RESULTS: Tumour-infiltrating lymphocyte scores were used to stratify p16+ cases, where tumours with absent/low levels of TIL had a relapse-free rate of 63%, as opposed to 92% with high levels of TIL (log rank P=0.006).

CONCLUSIONS: Assessment of TIL adds to p16 status in the prognosis of anal cancer following chemo-radiotherapy and provides evidence of the clinical importance of the immune response.

Original languageEnglish
JournalB J C
Volume114
Issue number2
Pages (from-to)134-7
Number of pages4
ISSN0007-0920
DOIs
Publication statusPublished - 19 Jan 2016

Keywords

  • Anus Neoplasms
  • Carcinoma, Squamous Cell
  • Chemoradiotherapy
  • Cohort Studies
  • Disease-Free Survival
  • Female
  • Humans
  • Immunohistochemistry
  • Kaplan-Meier Estimate
  • Lymphocytes, Tumor-Infiltrating
  • Male
  • Neoplasm Proteins
  • Papillomavirus Infections
  • Prognosis
  • Treatment Outcome
  • Journal Article
  • Research Support, Non-U.S. Gov't

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