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Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort study

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  • Dominique Castagliola
  • Bruno Ledergerber
  • Carlo Torti
  • Ard van Sighem
  • Daniel Podzamczer
  • Amanda Mocroft
  • Maria Dorrucci
  • Bernard Masquelier
  • Andrea de Luca
  • Klaus Jansen
  • Stephane De Wit
  • Niels Obel
  • Gerd Fätkenheuer
  • Giota Touloumi
  • Cristina Mussini
  • Antonella Castagna
  • Cristoph Stephan
  • Frederico Garcia
  • Robert Zangerle
  • Xavier Duval
  • Santiago Pérez-Hoyos
  • Laurence Meyer
  • Jade Ghosn
  • Céline Fabre-Colin
  • Jesper Kjaer
  • Genevieve Chene
  • Céline Fabre-Colin
  • Jesper Kjaer
  • Dominque Costagliola
  • Rebecca Lodwick
  • Bruno Ledergerber
  • Andrew Phillips
  • Pursuing Later Treatment Option II (PLATO II) project team
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Limited treatment options have been available for people with HIV who have had virological failure of the three original classes of HIV antiretroviral drugs-so-called triple-class virological failure (TCVF). However, introduction of new drugs and drug classes might have improved outcomes. We aimed to assess trends in virological and clinical outcomes for individuals with TCVF in 2000-09.
Original languageEnglish
JournalLancet Infectious Diseases
Volume12
Issue number2
Pages (from-to)119-27
Number of pages9
ISSN1473-3099
DOIs
Publication statusPublished - 2012

    Research areas

  • Adolescent, Adult, Anti-HIV Agents, CD4 Lymphocyte Count, Cohort Studies, Female, HIV Infections, HIV-1, Humans, Male, Middle Aged, RNA, Viral, Regression Analysis, Retrospective Studies, Young Adult

ID: 36469500