Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Trends in preadmission oral anticoagulant use and clinical outcome in atrial fibrillation patients admitted with acute stroke in Denmark

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Significant regional variation in use of implantable cardioverter-defibrillators in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Effect of impaired cardiac conduction after alcohol septal ablation on clinical outcomes: Insights from the Euro-ASA registry

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Living Alone is Associated with All-Cause and Cardiovascular Mortality: 32 years of follow-up in The Copenhagen Male Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Computer-Based Cognitive Rehabilitation in Patients with Visuospatial Neglect or Homonymous Hemianopia after Stroke

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Antiplatelets after intracerebral haemorrhage: treat the patient, not the brain imaging

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIMS: Use of oral anticoagulation therapy (OAC) has increased in recent years among patients with atrial fibrillation (AF). However, it remains uncertain whether this translates into improved clinical outcomes. We aimed to examine time trends in preadmission OAC use and clinical outcomes among AF patients admitted with stroke.

METHODS AND RESULTS: We used nationwide registries to perform a follow-up study of 14,999 patients with AF who were admitted with acute stroke to a Danish hospital between 2008 and 2016. The proportion of AF-related stroke was 16.1% in 2008 and 17.6% in 2016. Among patients with AF-related stroke, the overall proportion of preadmission OAC users increased from 22.6% in 2008 to 41.5% in 2016. Between 2008 and 2016 the proportion of patients with AF admitted with severe stroke declined from 32.4% to 27.4% (adjusted odds ratio [OR] = 0.78, 95% confidence interval [CI]: 0.75-0.81), the median length of hospital stay (LOS) decreased from 12 days to 8 days (adjusted hazard ratio of discharge = 1.32, 95% CI: 1.30-1.34) and 30-day mortality decreased from 19.2% to 13.7% (adjusted OR = 0.72, 95% CI: 0.68-0.75).

CONCLUSION: The incidence of AF-related strokes remains high although preadmission use of OAC has increased substantially in recent years. Despite the proportion of OAC users almost doubled from 2008 to 2016, a sizeable proportion of AF patients is still without OAC when admitted with stroke. The increased use of OAC has been accompanied by a lower proportion of patients with severe stroke, shorter LOS, and lower mortality.

Original languageEnglish
JournalEuropean heart journal. Quality of care & clinical outcomes
ISSN2058-5225
DOIs
Publication statusPublished - 19 Dec 2019

ID: 58954334